ArticleFrontiers in neuroscience2021
Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Brain Age Acceleration on MRI Due to Poor Sleep: Associations, Mechanisms, and Clinical Implications.Brain sciences · 2025Review
- Hypoxia's Impact on Hippocampal Functional Connectivity: Insights from Resting-State fMRI Studies.Brain sciences · 2025Review
- Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality.BMC medicine · 2025Article
- The Association between Obstructive Sleep Apnea and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study.Thrombosis and haemostasis · 2024Article
- Gut microbiota has important roles in the obstructive sleep apnea-induced inflammation and consequent neurocognitive impairment.Frontiers in microbiology · 2024Review
- Functional Connectivity Changes in Amygdala Subregions of Obstructive Sleep Apnea Patients After Six Months of Continuous Positive Airway Pressure Treatment.Nature and science of sleep · 2024Article
- Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure Treatment.Brain sciences · 2023Article
- Neurocognitive Consequences in Children with Sleep Disordered Breathing: Who Is at Risk?Children (Basel, Switzerland) · 2022Review
- Serum neurofilament light reflects cognitive dysfunctions in children with obstructive sleep apnea.BMC pediatrics · 2022Article
- Abnormal Functional Connectivity of Hippocampal Subdivisions in Obstructive Sleep Apnea: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2022Article
- The White Matter Functional Abnormalities in Patients with Transient Ischemic Attack: A Reinforcement Learning Approach.Neural plasticity · 2022Article
- Abnormal Spontaneous Brain Activity and Cognitive Impairment in Obstructive Sleep Apnea.Nature and science of sleep · 2022Article
- Abnormal Cerebral Blood Flow and Volumetric Brain Morphometry in Patients With Obstructive Sleep Apnea.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood obstructive sleep apnea (OSA) is a common chronic sleep-related breathing disorder in children, which leads to growth retardation, neurocognitive impairments, and serious complications. Considering the previous studies about brain structural abnormalities in OSA, in the present study, we aimed to explore the altered spontaneous brain activity among OSA patients, using amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) methods based on resting-state functional magnetic resonance imaging (MRI). Thirty-one untreated OSA children and 33 age-and gender-matched healthy children (HC) were included in this study. Compared with controls, the OSA group showed significant lower ALFF in the right lingual gyrus, decreased fALFF in the left middle frontal gyrus (MFG), but increased fALFF in the left precuneus. Decreased ReHo was found in the left inferior frontal gyrus (orbital part) and left middle frontal gyrus. Notably, the mean fALFF value of left MFG was not only significantly related to multiple sleep parameters but also demonstrated the best performance in ROC curve analysis. These findings revealed OSA children were associated with dysfunctions in the default mode network, the frontal lobe, and the lingual gyrus, which may implicate the underlying neurophysiological mechanisms of intrinsic brain activity. The correlation between the altered spontaneous neuronal activity and the clinical index provides early useful diagnostic biomarkers for OSA children as well.
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