Evidence map›Paper›PMID 34867080›Full record

ArticleEuropean journal of inorganic chemistry2021

Targeting Zinc Finger Proteins with Exogenous Metals and Molecules: Lessons learned from Tristetraprolin, a CCCH type Zinc Finger.

Kiwon Ok, Milos R Filipovic, Sarah L J Michel

Open access · greenAbstract read
In one paragraph

Article in European journal of inorganic chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. The past, present, and future of artificial zinc finger proteins: design strategies and chemical and biological applications.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Pooled it
  2. Review
  3. The first and second zinc finger domains from Poly-ADP-ribose polymerase 1 (PARP1) are modified by hydrogen sulfide.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  4. HBiochemistry · 2026
    Article
  5. Article
  6. Article
  7. Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for HAngewandte Chemie (International ed. in English) · 2024
    Article
  8. C(P)XCG Proteins ofInternational journal of molecular sciences · 2024
    Article
  9. Article
  10. Article
  11. Copper-binding proteins and exonic splicing enhancers and silencers.Metallomics : integrated biometal science · 2024
    Article
  12. Article
  13. Article
  14. Pb(II) coordination to the nonclassical zinc finger tristetraprolin: retained function with an altered fold.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Kiwon OkDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Milos R FilipovicLeibniz-Institut für Analytische, Wissenschaften-ISAS-e.V., 44227 Dortmund, Germany.
Sarah L J MichelDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USLeibniz Institute for Analytical Sciences - ISAS · DE

Funding

The Role of Zinc Fingers in H2S SignalingR01GM139854 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI MICHEL, SARAH L · 2020 to 2023
$1.5M
NIGMS NIH HHS R01 GM139854
6 · The paper itself

Abstract

ZF proteins are ubiquitous eukaryotic proteins that play important roles in gene regulation. ZFs contain small domains made up of a combination of four cysteine and histidine residues, and are classified based up on the identity of these residues and their spacing. One emerging class of ZFs are the Cys

Indexed as

Hydrogen sulfideProtein-RNA interactionsReplacement of metal ionsZinc finger proteins

Identifiers

PMID34867080
PMCPMC8635303
OpenAlexW3183255803

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.