Evidence map›Paper›PMID 34867030›Full record

ArticleSaudi journal of biological sciences2021

Andina Setyawati, Mae Sri Hartati Wahyuningsih, Dwi Aris Agung Nugrahaningsih, Christantie Effendy, Firas Fneish, Gerhard Fortwengel

4 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in Saudi journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06676124 nacompletednot on this mapstarted 2024, after this paper: background citation

Modulation of MMP-9/NGAL Ratio in Diabetic Patients With Early Renal Dysfunction by Piper Crocatum Functional Foods

TypeinterventionalSponsorHasanuddin UniversityRan2024 to 2024Enrolled387ConditionsEarly Renal Dysfunction in Diabetes, Diabetic Nephropathy, Inflammation and Oxidative Stress in Diabetic PatientsArmsPiper crocatum Extract Cookie, Placebo Comparator
NCT07187648 nacompletednot on this mapstarted 2025, after this paper: background citation

The Effect of Golden Rice Cookies With Piper Crocatum on Fasting Blood Sugar and Quality of Life in People Living With HIV With Hyperglycemia

TypeinterventionalSponsorHasanuddin UniversityRan2025 to 2025Enrolled102ConditionsHIV Infections, Nutritional Intervention, Blood Glucose, Quality of LifeArmsGolden Rice Cookies With Piper crocatum, Iso-Caloric Control Cookies (Placebo)
NCT07268781 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

The Effect of Golden Rice Cookies With Piper Crocatum Extract on Lipid Profile Control in Patients With Diabetes Mellitus

TypeinterventionalSponsorHasanuddin UniversityRan2025 to 2025Enrolled102ConditionsDiabetes Mellitus (DM), Dyslipidemia, Lipid Profile, Functional FoodArmsGolden Rice cookies with Piper crocatum Extract, Placebo Cookies (Control)
NCT07272993 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

The Effect of Golden Rice Cookies With Piper Crocatum on the Prevention of Diabetic Neuropathy in Patients With Diabetes Mellitus

TypeinterventionalSponsorHasanuddin UniversityRan2025 to 2025Enrolled102ConditionsDiabetic Neuropathy, Diabetes Mellitus (DM), Functional Food, Nutritional InterventionArmsGolden Rice Cookies With Piper Crocatum, Golden Rice Cookies Without Piper Crocatum
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Mechanism of the effect ofOpen veterinary journal · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Andina SetyawatiLecturer of Department of Surgical and Medical Nursing, Faculty of Nursing, Universitas Hasanuddin, Jl. Perintis Kemerdekaan km 10, Kampus Tamalanrea, Makassar 90245, Indonesia.
Mae Sri Hartati WahyuningsihLecturer of Department of Pharmacology and Therapy, Centre for Herbal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Jl. Senolowo, Sekip Utara, Depok, Sleman, Yogyakarta 55281, Indonesia.
Dwi Aris Agung NugrahaningsihLecturer of Department of Pharmacology and Therapy, Centre for Herbal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Jl. Senolowo, Sekip Utara, Depok, Sleman, Yogyakarta 55281, Indonesia.
Christantie EffendyLecturer of Department of Surgical and Medical Nursing, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Jl. Senolowo, Sekip Utara, Depok, Sleman, Yogyakarta 55281, Indonesia.
Firas FneishLecturer of Department of Biostatistics, Gottfried Wilhelm Leibniz Universität, Postfach 6009, 30060 Hannover, Germany.
Gerhard FortwengelLecturer of Department of Clinical Research and Epidemiology, Hochschule Hannover University of Applied Sciences & Arts, Expo Plaza 12, 30539 Hannover, Germany.
Universitas Gadjah Mada · IDHasanuddin University · IDHochschule Hannover · DELeibniz University Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction

methodsBioassay-guided fractionation was performed to get the most active fraction. The selected active fraction was applied to wHFs within 72 h incubation. Mimicking a diabetic condition was done using basal glucose media containing an additional 17 mMol/L D-glucose. A wound was simulated via the scratch assay. The collagen deposition was measured using Picro-Sirius Red and wound closure was measured using scratch wound assay. Underlying mechanisms through p53, αSMA, SOD1 and E-cadherin were measured using western blotting.

resultsWe reported that F DISCUSSION/

conclusionsOur findings suggest that ameliorating collagen deposition and wound closure through protein regulation of p53, αSMA, E-cadherin, and SOD1 are some of the mechanisms by which F

Indexed as

CHCl3, ChloroformDiabetic wound healingDMEM, Dulbecco's Modified Eagle's MediumE-cadherinETOAc, Ethyl acetateHFs, Hyperglycemia fibroblastsMechanismMeOH, MethanolMTT, 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromideNFs, Normal fibroblastsp53p53, tumor suppressor proteinPiper crocatum Ruiz & PavROS, Reactive oxygen speciesSOD1SOD1, superoxide dismutase 1TLC, Thin layer chromatographyWB, Washed benzenewHFs, wounded hyperglycemia fibroblastsαSMA, alpha smooth muscle actin

Identifiers

PMID34867030
PMCPMC8626332
OpenAlexW3193595789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.