Evidence map›Paper›PMID 34867019›Full record

ReviewSaudi journal of biological sciences2021

Ultrastructural study of collagen fibrils, proteoglycans and lamellae of the cornea treated with iontophoresis - UVA cross-linking and hypotonic riboflavin solution.

Turki Almubrad, Rita Mencucci, Adrian Smedowski, Ramachandran Samivel, Essam Almutleb, Aljoharah Alkanaan, Adnan Ali Khan, Ali Masmali, Saeed Akhtar

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Saudi journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. [Controllability and predictability of riboflavin-ultraviolet A collagen cross-linking: advances in experimental techniques and theoretical research].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Turki AlmubradCornea Research Chair, Department of Optics and Vision Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
Rita MencucciDepartment of Oto-Neuro-Ophthalmology Surgical Sciences, Eye Clinic, University of Florence, Italy.
Adrian SmedowskiDepartment of Physiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Ramachandran SamivelCornea Research Chair, Department of Optics and Vision Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
Essam AlmutlebCornea Research Chair, Department of Optics and Vision Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
Aljoharah AlkanaanCornea Research Chair, Department of Optics and Vision Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
Adnan Ali KhanCornea Research Chair, Department of Optics and Vision Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
Ali MasmaliCornea Research Chair, Department of Optics and Vision Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
Saeed AkhtarCornea Research Chair, Department of Optics and Vision Sciences, College of Applied Medical Science, King Saud University, Riyadh, Saudi Arabia.
King Saud University · SAMedical University of Silesia · PLUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the effects of iontophoresis-ultraviolet A (UVA) cross-linking (CXL) with hypotonic riboflavin solution on the ultrastructural changes in the lamellae, collagen fibrils (CFs), and proteoglycans (PGs) in the central and peripheral stroma of the human corneal buttons. The iontophoresis method was used for the

Indexed as

Collagen fibrilsCorneaIontophoresisProteoglycansUltraviolet A

Identifiers

PMID34867019
PMCPMC8626267
OpenAlexW3188949991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.