ArticleInternational journal of general medicine2021
Association Between HDL-C and Bone Mineral Density: An Cross-Sectional Analysis.
Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Sex differences in the association between bone mineral density and lipid profiles in people with type 2 diabetes in southwest China.Metabolism open · 2026Article
- The relationship between the polymorphisms and mutations of OPG gene and bone metabolism in postmenopausal women in northwest China.Journal of orthopaedic surgery and research · 2026Article
- Adiposity-lipid-glycemic clusters as potential warning signals of bone mass reduction in Asia's largest urban communities - based bone health assessment via ultrasound.Lipids in health and disease · 2025Article
- Analysis of the efficacy and safety of denosumab in the treatment of patients with osteoporotic vertebral compression fractures after PVP.Scientific reports · 2025Article
- Causal Relationship Between Blood Metabolites and Osteoporosis: A Two-Sample Mendelian Randomization and Genetic Correlation Analysis.Bioengineering (Basel, Switzerland) · 2025Article
- The diagnostic value of the combined application of blood lipid metabolism markers and interleukin-6 in osteoporosis and osteopenia.Lipids in health and disease · 2025Article
- A Retrospective Machine Learning Analysis to Predict 3-Month Nonunion of Unstable Distal Clavicle Fracture Patients Treated with Open Reduction and Internal Fixation.Therapeutics and clinical risk management · 2025Article
- Risk of myocardial infarction and Osteoporosis: Insights from the 2015-2018 NHANES and Mendelian randomization Studies.International journal of cardiology. Heart & vasculature · 2024Article
- The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of osteoporosis among U.S. adults: analysis of NHANES data.Lipids in health and disease · 2024Article
- Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass index.BMC musculoskeletal disorders · 2024Article
- Unraveling the role of serum metabolites in the relationship between plant-based diets and bone health in community-dwelling older adults.Current research in food science · 2024Article
- The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis.Biomedicines · 2023Review
- The correlation between high-density lipoprotein cholesterol and bone mineral density in adolescents: a cross-sectional study.Scientific reports · 2023Article
- Correlation between Blood Lipid Level and Osteoporosis in Older Adults with Type 2 Diabetes Mellitus-A Retrospective Study Based on Inpatients in Beijing, China.Biomolecules · 2023Article
- Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study.Journal of orthopaedic surgery and research · 2023Article
- The Paradoxical Association of Lipids with Survival and Walking Ability of Hip Fractures in Geriatric Patients After Surgery: A 1-Year Follow-Up Study.International journal of general medicine · 2023Article
- High cholesterol and low triglycerides are associated with total lumbar bone mineral density among adults aged 50 years and over: The NHANES 2017-2020.Frontiers in medicine · 2022Article
- The role of metabolites under the influence of genes and lifestyles in bone density changes.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDyslipidemia has been found to contribute to increased risk of osteoporosis and its association with bone mineral density (BMD) remains controversial. We determined whether blood lipid levels are linked with change of BMD.
methodsIn a large sample from the MIDUS II study, we sought to evaluate the relationship between blood lipid levels and BMD. Multivariate linear regression models and smooth curve analysis were constructed by controlling a great range of confounding factors.
resultsThe median age of them was 52.5 years, and the number of males was 176 (40%). Univariate analysis showed that blood high-density lipoprotein-cholesterol (HDL-C) level was negatively related to lunar total femur (r = -0.266, P < 0.001), lunar radius ultradistal (UD) (r = -0.297, P < 0.001), lunar radius 1/3 (r = -0.307, P = 0.001) and femoral neck (r = -0.172, P = 0.001). In multivariate linear analysis, except for blood triglyceride, total cholesterol and low-density lipoprotein cholesterol (LDL-C), we found that blood HDL-C level was still negatively related to lunar total femur [B = -0.002, B 95% CI (-0.002, -0.001), P < 0.001], lunar radius UD [B = -0.001, 95% CI (-0.001, 0), P = 0.002], lunar radius 1/3 [B = -0.001, 95% CI (-0.001, 0), P = 0.003] and femoral neck [B = -0.001, 95% CI (-0.002, 0), P = 0.039] after adjustments of demographic characteristics, lifestyle, disease history were made. Furthermore, we found that age, sex, and body mass index (BMI) had modifying effects on this negative association.
conclusionThis study confirmed the negative association between HDL-C and BMD in the observational analysis from (MIDUS) study and provides high-quality evidence that age, sex and BMI had modifying effects on this negative association.
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