Evidence map›Paper›PMID 34866915›Full record

ArticleOncoTargets and therapy2021

Favorable Response to Olaparib in a Patient with Cancer of Unknown Primary Carrying a Germline BRCA1 R71K Mutation.

Xiaomeng Jia, Shanshan Zhao, Xiang Li, Li Lv, Xin Chen, Evenki Pan, Qiuxiang Ou, Chen Song, Siwen Sun, Jinbo Zhao and 2 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in OncoTargets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Xiaomeng Jia *Department of Oncology, The Second Hospital of Dalian Medical University, Dalian, 116023, People's Republic of China.
Shanshan Zhao *Department of Oncology, The Second Hospital of Dalian Medical University, Dalian, 116023, People's Republic of China.
Xiang Li *Department of Radiology, The Second Hospital of Dalian Medical University, Dalian, 116023, People's Republic of China.
Li Lv *Department of Pathology, The Second Hospital of Dalian Medical University, Dalian, 116023, People's Republic of China.
Xin ChenGeneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, 210032, People's Republic of China.ORCID 0000-0003-1871-4477
Evenki PanGeneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, 210032, People's Republic of China.
Qiuxiang OuGeneseeq Research Institute, Nanjing Geneseeq Technology Inc., Nanjing, 210032, People's Republic of China.ORCID 0000-0002-2961-2057
Chen SongDepartment of Oncology, The Second Hospital of Dalian Medical University, Dalian, 116023, People's Republic of China.
Siwen SunDepartment of Oncology, The Second Hospital of Dalian Medical University, Dalian, 116023, People's Republic of China.
Jinbo ZhaoDepartment of Oncology, The Second Hospital of Dalian Medical University, Dalian, 116023, People's Republic of China.
Lingzhi XuDepartment of Oncology, The Second Hospital of Dalian Medical University, Dalian, 116023, People's Republic of China.
Man LiDepartment of Oncology, The Second Hospital of Dalian Medical University, Dalian, 116023, People's Republic of China.
Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment options for cancer of unknown primary (CUP) are challenging due to the lack of knowledge about the primary sites, often resulting in a poor prognosis. The emerging next-generation sequencing (NGS) technique has provided a reliable approach to facilitate tumor primary site prediction and targetable gene alteration identification for CUP patients. In this report, we described a 63-year-old female patient who experienced recurrent CUP. NGS-based genetic profiling results revealed a pathogenic germline

Indexed as

BRCA1 germline mutationcancer of unknown primarynext-generation sequencingolaparib

Identifiers

PMID34866915
PMCPMC8636970
OpenAlexW3215397483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.