Evidence map›Paper›PMID 34866896›Full record

ArticleCancer informatics2021

Sparse Regression in Cancer Genomics: Comparing Variable Selection and Predictions in Real World Data.

Robert J O'Shea, Sophia Tsoka, Gary Jr Cook, Vicky Goh

Abstract read
In one paragraph

Article in Cancer informatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert J O'SheaDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0003-4983-7912
Sophia TsokaDepartment of Informatics, School of Natural and Mathematical Sciences, King's College London, London, UK.
Gary Jr CookDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.ORCID https://orcid.org/0000-0002-8732-8134
Vicky GohDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

Funding

Cancer Research UK 16463Wellcome Trust
6 · The paper itself

Abstract

backgroundEvaluation of gene interaction models in cancer genomics is challenging, as the true distribution is uncertain. Previous analyses have benchmarked models using synthetic data or databases of experimentally verified interactions - approaches which are susceptible to misrepresentation and incompleteness, respectively. The objectives of this analysis are to (1) provide a real-world data-driven approach for comparing performance of genomic model inference algorithms, (2) compare the performance of LASSO, elastic net, best-subset selection,

methodsFive large

results

conclusionsThis analysis explores a novel approach for comparisons of model selection approaches in real genomic data from 5 cancers. Our benchmarking datasets have been made publicly available for use in future research. Our findings support the use of

Indexed as

Artificial intelligencecomputational biologygene regulatory networksgenomicsmodelsstatistical

Identifiers

PMID34866896
PMCPMC8640984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.