Evidence map›Paper›PMID 34866842›Full record

ArticleJournal of clinical and experimental hepatology

Adipocytokines as Risk Factors for Development of Nonalcoholic Fatty Liver Disease in Children.

Paweł Małecki, Anna Mania, Joanna Tracz, Magdalena Łuczak, Katarzyna Mazur-Melewska, Magdalena Figlerowicz

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Biomarkers in Fatty Liver Disease-Here is the Skinny.Journal of clinical and experimental hepatology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Paweł MałeckiDepartment of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Poznan, Poland.
Anna ManiaDepartment of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Poznan, Poland.
Joanna TraczInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Magdalena ŁuczakInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Katarzyna Mazur-MelewskaDepartment of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Poznan, Poland.
Magdalena FiglerowiczDepartment of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Poznan, Poland.
Poznan University of Medical Sciences · PLInstitute of Bioorganic Chemistry, Polish Academy of Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNoninvasive diagnostics of nonalcoholic fatty liver disease (NAFLD), the most common cause of liver dysfunction in children, are based on imaging, biochemical tests and their compilation. The study aimed to evaluate the serological biomarkers of steatosis, inflammation and liver fibrosis to assess the risk of NAFLD in children.

methodsA total of 73 children were included in the prospective study; 50 of them were diagnosed with NAFLD based on ultrasound, and 23 formed a control group. Basic anthropometric parameters were measured, blood samples were taken for laboratory tests and evaluated proteins were assessed by enzyme-linked immunosorbent assay-adiponectin, tumour necrosis factor alpha, fibroblast growth factor 21, liver fatty acid-binding protein (L-FABP) and interleukin 6.

resultsStatistically significant differences between the levels of two proteins were found: the adiponectin level was lower in the NAFLD group (12.24 ± 7.01 vs 16.88 ± 9.21 μg/mL,

conclusionAdiponectin may be useful in evaluating the risk of NAFLD and obesity in children.

Indexed as

adipokinesALF, acute liver failureALT, alanine aminotransferaseAMPK, adenosine monophosphate–activated protein kinaseAPRI, AST to Platelet Ratio IndexAST, aspartate aminotransferaseBMI, body mass indexchildrenER, endoplasmic reticulumFFA, free fatty acidFGF-21, fibroblast growth factor 21HMW, high-molecular-weightIR, insulin resistanceL-FABP, liver fatty acid-binding proteinLPS, lipopolysaccharideNAFLD, nonalcoholic fatty liver diseaseNASH, nonalcoholic steatohepatitisnonalcoholic fatty liver diseaseOR, odds ratioPNFS, Paediatric NAFLD Fibrosis ScalePPAR-α, peroxisome proliferator–activated receptor-αSD, standard deviationSOCS3, suppressor of cytokine signalling 3TNF-α, tumour necrosis factor αUS-FLI, ultrasound fatty liver indicatorWHO, World Health Organization

Identifiers

PMID34866842
PMCPMC8617538
OpenAlexW3134331644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.