ArticleSensors and actuators. B, Chemical2022
Molecularly imprinted polymer based electrochemical sensor for quantitative detection of SARS-CoV-2 spike protein.
Article in Sensors and actuators. B, Chemical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Analytical applications of molecularly imprinted polymers: a personal view.Analytical and bioanalytical chemistry · 2026Review
- Dual template (epitope) imprinting of Mycobacterium leprae bacterial protein for enhanced MIP-EQCM sensing.Analytical and bioanalytical chemistry · 2026Article
- Recent advances in MXene-molecularly imprinted polymer hybrid nanocomposites for electrochemical detection of pandemic-related biomarkers.Analytical and bioanalytical chemistry · 2026Review
- Progress and Perspectives of Molecular Imprinting Methods in the Development of Electrochemical Protein Biosensors.Biosensors · 2026Review
- Nano-engineered biomimetic materials: toward point-of-care diagnosis of infectious diseases.Mikrochimica acta · 2025Review
- A Wearable Electrochemical Biosensor for Salivary Detection of Periodontal Inflammation Biomarkers: Molecularly Imprinted Polymer Sensor with Deep Learning Integration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mpox disease, diagnosis, and point of care platforms.Bioengineering & translational medicine · 2025Review
- PULSE: A Fast Portable Unit for Lab-on-Site Electrochemistry.Sensors (Basel, Switzerland) · 2025Article
- Electrochemical Immunosensors on Laser-Induced Graphene Platforms for Monitoring of Anti-RBD Antibodies After SARS-CoV-2 Infection.Biosensors · 2024Article
- Molecularly Imprinted Viral Protein Integrated Zn-Cu-In-Se-P Quantum Dots Superlattice for Quantitative Ratiometric Electrochemical Detection of SARS-CoV-2 Spike Protein in Saliva.ACS applied nano materials · 2024Article
- Effect of Various Carbon Electrodes on MIP-Based Sensing Proteins Using Poly(Scopoletin): A Case Study of Ferritin.Biomimetics (Basel, Switzerland) · 2024Article
- Molecularly imprinted polymer-based extended-gate field-effect transistor chemosensors for selective determination of antiepileptic drug.Mikrochimica acta · 2024Article
- Measurement of neuropeptide Y with molecularly imprinted polypyrrole on carbon fiber microelectrodes.Neuropeptides · 2024Article
- Review
- Low-Cost Biosensor Technologies for Rapid Detection of COVID-19 and Future Pandemics.ACS nano · 2024Review
- Advances in nanobiosensors during the COVID-19 pandemic and future perspectives for the post-COVID era.Nano convergence · 2024Review
- On-site airborne pathogen detection for infection risk mitigation.Chemical Society reviews · 2023Review
- Carbon Nanostructured Immunosensing of Anti-SARS-CoV-2 S-Protein Antibodies.Molecules (Basel, Switzerland) · 2023Article
- Mobile Point-of-Care Device Using Molecularly Imprinted Polymer-Based Chemosensors Targeting Interleukin-1β Biomarker.Biosensors · 2023Article
- Recent Advances in Molecularly Imprinted Polymers and Their Disease-Related Applications.Polymers · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The continued spread of the coronavirus disease and prevalence of the global pandemic is exacerbated by the increase in the number of asymptomatic individuals who unknowingly spread the SARS-CoV-2 virus. Although remarkable progress is being achieved at curtailing further rampage of the disease, there is still the demand for simple and rapid diagnostic tools for early detection of the COVID-19 infection and the following isolation. We report the fabrication of an electrochemical sensor based on a molecularly imprinted polymer synthetic receptor for the quantitative detection of SARS-CoV-2 spike protein subunit S1 (ncovS1), by harnessing the covalent interaction between 1,2-diols of the highly glycosylated protein and the boronic acid group of 3-aminophenylboronic acid (APBA). The sensor displays a satisfactory performance with a reaction time of 15 min and is capable of detecting ncovS1 both in phosphate buffered saline and patient's nasopharyngeal samples with LOD values of 15 fM and 64 fM, respectively. Moreover, the sensor is compatible with portable potentiostats thus allowing on-site measurements thereby holding a great potential as a point-of-care testing platform for rapid and early diagnosis of COVID-19 patients.
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