Evidence map›Paper›PMID 34866655›Full record

ArticleJournal of physics D: Applied physics2021

Quantifying molecular- to cellular-level forces in living cells.

Jason Pan, Tommy Kmieciak, Yen-Ting Liu, Matthew Wildenradt, Yun-Sheng Chen, Yang Zhao

Abstract read
In one paragraph

Article in Journal of physics D: Applied physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Modulating a Massive Set of Biomolecular Structures by Sono-Mechanical Force.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jason PanDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States of America.ORCID 0000-0002-3481-8703
Tommy KmieciakDepartment of Engineering Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States of America.
Yen-Ting LiuDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States of America.ORCID 0000-0002-5768-0516
Matthew WildenradtDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States of America.
Yun-Sheng ChenDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States of America.ORCID 0000-0001-8823-970X
Yang ZhaoDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States of America.ORCID 0000-0002-0154-3483

Funding

SINGLE MOLECULAR NANOSCOPIC IMAGING ON LIVING CELLSR21GM139022 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZHAO, YANG · 2020 to 2021
$436k
NIGMS NIH HHS R21 GM139022
6 · The paper itself

Abstract

Mechanical cues have been suggested to play an important role in cell functions and cell fate determination, however, such physical quantities are challenging to directly measure in living cells with single molecule sensitivity and resolution. In this review, we focus on two main technologies that are promising in probing forces at the single molecule level. We review their theoretical fundamentals, recent technical advancements, and future directions, tailored specifically for interrogating mechanosensitive molecules in live cells.

Indexed as

atomic force microscopyconformational imagingFRETmechanobiologymolecular forces

Identifiers

PMID34866655
PMCPMC8635116

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.