ArticleThe Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2023
Neurological Presentations in Patients with COVID-19 in Cytokine Storm.
Article in The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Clinical Features of Central Nervous System Complications Caused by the SARS-CoV-2 Omicron Variant.Immunity, inflammation and disease · 2025Article
- Clinical features and outcomes of nine children with acute necrotizing encephalopathy.Frontiers in pediatrics · 2025Article
- Mesenchymal Stem Cell-Based Therapies in the Post-Acute Neurological COVID Syndrome: Current Landscape and Opportunities.Biomolecules · 2023Review
- The Impact of COVID-19 on People Living with HIV-1 and HIV-1-Associated Neurological Complications.Viruses · 2023Review
- A fatal case of COVID-19-associated meningoencephalitis in a patient coinfected with influenza A.Revista do Instituto de Medicina Tropical de Sao Paulo · 2023Article
- Clinical Characteristics of Myasthenia Gravis Patients with COVID-19 in Guangxi, China: A Case-Control Study.Journal of inflammation research · 2023Article
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Authors and funding
10 authors.
Funding
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Abstract
backgroundCoronavirus disease 2019 (COVID-19) infection causes a wide variety of neurological disorders by affecting both central and peripheral nervous systems. The cytokine storm (CS) has been blamed for the development of severe neurological disorders in COVID-19. However, the relationship between COVID-19 CS and neurological manifestations has not been adequately studied. Thus, we aimed to investigate the neurological presentations in patients with COVID-19 CS.
methodsThe study population consisted of hospitalized moderate-to-severe COVID-19 patients. It was divided into two groups CS (36 patients, 29.3%) and non-CS (87 patients, 70.7%) based on significant clinical symptoms, elevated inflammatory marker levels, radiological findings, and interleukin-6 levels (IL-6).
resultsThe three most common neurological symptoms in the CS group were altered level of consciousness, headache, and unsteadiness. Altered level of consciousness was higher in the CS group (69.4%) than the non-CS group (25.3%) (
conclusionThe most common neurological presentation in patients with CS was altered level of consciousness. The presence of CS was an independent risk factor for high mortality.
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