Evidence map›Paper›PMID 34866453›Full record

ArticleJournal of child neurology2022

Spasticity and Dystonia are Underidentified in Young Children at High Risk for Cerebral Palsy.

Hanyang Miao, Amit M Mathur, Bhooma R Aravamuthan

Open access · greenAbstract read
In one paragraph

Article in Journal of child neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Thalamic deep brain stimulation improves movement in a cerebellar model of lesion-based status dystonicus.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  6. Article
  7. Article
  8. Caregiver descriptions of dystonia in cerebral palsy.Annals of clinical and translational neurology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Determinants of gait dystonia severity in cerebral palsy.Developmental medicine and child neurology · 2023
    Article
  13. Under-recognition of leg dystonia in people with cerebral palsy.Annals of the Child Neurology Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hanyang Miao12275Washington University School of Medicine and St Louis Children's Hospital, St Louis, MO, USA.ORCID 0000-0001-5757-859X
Amit M Mathur12274St Louis University and Cardinal Glennon Children's Hospital, St Louis, MO, USA.
Bhooma R Aravamuthan12275Washington University School of Medicine and St Louis Children's Hospital, St Louis, MO, USA.ORCID 0000-0003-0205-2149
St. Louis Children's Hospital · USCardinal Glennon Children’s Medical Center · US

Funding

Child Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2M
Modulation of striatal cholinergic interneuron activity to prevent dystonic cerebral palsyK08NS117850 · NINDS · WASHINGTON UNIVERSITY · PI ARAVAMUTHAN, BHOOMA · 2021 to 2025
$927k
NINDS NIH HHS K08 NS117850NINDS NIH HHS K12 NS098482
6 · The paper itself

Abstract

backgroundEarly spasticity and dystonia identification in cerebral palsy is critical for guiding diagnostic workup and prompting targeted treatment early when it is most efficacious. However, differentiating spasticity from dystonia is difficult in young children with cerebral palsy.

methodsWe sought to determine spasticity and dystonia underidentification rates in children at high risk for cerebral palsy (following neonatal hypoxic-ischemic encephalopathy) by assessing how often child neurologists identified hypertonia alone versus specifying the hypertonia type as spasticity and/or dystonia by age 5 years.

resultsOf 168 children, 63 developed cerebral palsy and hypertonia but only 19 (30%) had their hypertonia type specified as spasticity and/or dystonia by age 5 years.

conclusionsChild neurologists did not specify the type of hypertonia in a majority of children at high risk of cerebral palsy. Because early tone identification critically guides diagnostic workup and treatment of cerebral palsy, these results highlight an important gap in current cerebral palsy care.

Indexed as

Cerebral PalsyChild, PreschoolDystoniaFemaleHumansInfantMaleMissouriMuscle SpasticityRetrospective StudiesRisk AssessmentSurveys and Questionnairescerebral palsydevelopmental disabilitydystoniahypoxic-ischemic encephalopathyspasticity

Identifiers

PMID34866453
PMCPMC9650959
OpenAlexW4200034467

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.