Evidence map›Paper›PMID 34866280›Full record

ArticleCancer science2022

Retinol binding protein 1-dependent activation of NF- κB signaling enhances the malignancy of non-glioblastomatous diffuse gliomas.

Wei Wu, Yichang Wang, Chen Niu, Alafate Wahafu, Longwei Huo, Xiaoye Guo, Jianyang Xiang, Xiaodong Li, Wanfu Xie, Xiaobin Bai and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Coronary artery disease-associated immune geneFrontiers in cardiovascular medicine · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Wei WuDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.ORCID https://orcid.org/0000-0002-5098-7953
Yichang WangDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.ORCID https://orcid.org/0000-0002-3128-7193
Chen NiuDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Alafate WahafuDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Longwei HuoDepartment of Neurosurgery, Yulin First Hospital Affiliated to Xi'an Jiao Tong University, Yulin, China.
Xiaoye GuoDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jianyang XiangDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xiaodong LiDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wanfu XieDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xiaobin BaiDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Maode WangDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Jia WangDepartment of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.ORCID https://orcid.org/0000-0002-4746-035X
First Affiliated Hospital of Xi'an Jiaotong University · CNYulin University · CN

Funding

Fundamental Research Funds of Xi'an Jiaotong University 1191329177Natural Science Basic Research Plan in Shaanxi Province of China 2019JQ-958The National Natural Science Foundation of China 81802502
6 · The paper itself

Abstract

Nonglioblastomatous diffuse glioma (non-GDG) is a heterogeneous neuroepithelial tumor that exhibits a varied survival range from 4 to 13 years based on the diverse subtypes. Recent studies demonstrated novel molecular markers can predict prognosis for non-GDG patients; however, these findings as well as pathological classification strategies show obvious limitations on malignant transition due to the heterogeneity among non-GDGs. Therefore, developing reliable prognostic biomarkers and therapeutic targets have become an urgent need for precisely distinguishing non-GDG subtypes, illuminating the underlying mechanism. Nuclear factor κβ (NF-κB) has been proved to be a significant nuclear transcriptional regulator with specific DNA-binding sequences to participate in multiple pathophysiological processes. However, the underlying mechanism of NF-κB activation still needs to be further investigated. Herein, our results indicated retinol-binding protein 1 (RBP1) was significantly upregulated in the IDH

Indexed as

Biomarkers, TumorCell MovementCell ProliferationCell Transformation, NeoplasticEpithelial-Mesenchymal TransitionGliomaHumansI-kappa B KinaseIsocitrate DehydrogenaseNF-kappa BPhosphorylationPrognosisRetinol-Binding Proteins, CellularSignal TransductionTumor Necrosis Factor-alphaBiomarkers, TumorCHUK protein, humanI-kappa B KinaseIsocitrate DehydrogenaseNF-kappa BRBP1 protein, humanRetinol-Binding Proteins, CellularTumor Necrosis Factor-alphaEMT-like phenotypesNF-κB signalingnon-GDGprognostic biomarkerRBP1

Identifiers

PMID34866280
PMCPMC8819305
OpenAlexW4200339140

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.