Evidence map›Paper›PMID 34866236›Full record

ArticleMagnetic resonance in medicine2022

Echo planar imaging-induced errors in intracardiac 4D flow MRI quantification.

Jos J M Westenberg, Hans C van Assen, Pieter J van den Boogaard, Jelle J Goeman, Hicham Saaid, Jason Voorneveld, Johan Bosch, Sasa Kenjeres, Tom Claessens, Pankaj Garg and 2 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Comparison of Echo-Planar Imaging and Compressed Sensing in the Estimation of Flow Metrics from Aortic 4D Flow MR Imaging: A Healthy Volunteer Study.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  3. Article
  4. Age- and sex-specific reference values of biventricular flow components and kinetic energy by 4D flow cardiovascular magnetic resonance in healthy subjects.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Observational
  5. 4D Flow cardiovascular magnetic resonance consensus statement: 2023 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Review
  6. Article
  7. Rationale and clinical applications of 4D flow cardiovascular magnetic resonance in assessment of valvular heart disease: a comprehensive review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Review
  8. Article
  9. Why 4D Flow MRI? Real Advantages.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jos J M WestenbergCardioVascular Imaging Group, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0003-1946-1715
Hans C van AssenCardioVascular Imaging Group, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Pieter J van den BoogaardCardioVascular Imaging Group, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Jelle J GoemanDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
Hicham SaaidInstitute Biomedical Technology, Ghent University, Ghent, Belgium.
Jason VoorneveldDepartment of Biomedical Engineering, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
Johan BoschDepartment of Biomedical Engineering, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.
Sasa KenjeresDepartment of Chemical Engineering, Delft University of Technology, Delft, the Netherlands.
Tom ClaessensDepartment of Materials, Textiles and Chemical Engineering, Ghent University, Ghent, Belgium.
Pankaj GargDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Marc KouwenhovenDepartment of MR R&D-Clinical Science, Philips, Best, the Netherlands.
Hildo J LambCardioVascular Imaging Group, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess errors associated with EPI-accelerated intracardiac 4D flow MRI (4DEPI) with EPI factor 5, compared with non-EPI gradient echo (4DGRE).

methodsThree 3T MRI experiments were performed comparing 4DEPI to 4DGRE: steady flow through straight tubes, pulsatile flow in a left-ventricle phantom, and intracardiac flow in 10 healthy volunteers. For each experiment, 4DEPI was repeated with readout and blip phase-encoding gradient in different orientations, parallel or perpendicular to the flow direction. In vitro flow rates were compared with timed volumetric collection. In the left-ventricle phantom and in vivo, voxel-based speed and spatio-temporal median speed were compared between sequences, as well as mitral and aortic transvalvular net forward volume.

resultsIn steady-flow phantoms, the flow rate error was largest (12%) for high velocity (>2 m/s) with 4DEPI readout gradient parallel to the flow. Voxel-based speed and median speed in the left-ventricle phantom were ≤5.5% different between sequences. In vivo, mean net forward volume inconsistency was largest (6.4 ± 8.5%) for 4DEPI with nonblip phase-encoding gradient parallel to the main flow. The difference in median speed for 4DEPI versus 4DGRE was largest (9%) when the 4DEPI readout gradient was parallel to the flow.

conclusionsVelocity and flow rate are inaccurate for 4DEPI with EPI factor 5 when flow is parallel to the readout or blip phase-encoding gradient. However, mean differences in flow rate, voxel-based speed, and spatio-temporal median speed were acceptable (≤10%) when comparing 4DEPI to 4DGRE for intracardiac flow in healthy volunteers.

Indexed as

Echo-Planar ImagingImaging, Three-DimensionalBlood Flow VelocityHeartHumansMagnetic Resonance ImagingPhantoms, Imaging4D flow MRIecho planar imagingintracardiac blood flowphase-contrast MRI

Identifiers

PMID34866236
PMCPMC9300143

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.