ArticlePlant, cell & environment2022
A conserved clathrin-coated vesicle component, OsSCYL2, regulates plant innate immunity in rice.
Article in Plant, cell & environment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 17 citations in OpenAlex.
- The potential of metabolic engineering for sustainable phytosterol production.Advanced biotechnology · 2026Review
- Genome-wide identification and characterization of DUF789 genes in cotton: implications for fibre development.BMC plant biology · 2025Article
- Lesion Mimic Mutant: An Ideal Genetic Material for Deciphering the Balance Between Plant Immunity and Growth.Rice (New York, N.Y.) · 2025Review
- Article
- Genetic characterization and linkage analysis of spotted leaf 6,liguleless and lax panicle traits in mutant rice.Journal of genetics · 2024Article
- A single amino acid substitution in the AAA-type ATPase LRD6-6 activates immune responses but decreases grain quality in rice.Frontiers in plant science · 2024Article
- Uptake of oomycete RXLR effectors into host cells by clathrin-mediated endocytosis.The Plant cell · 2023Article
- Identification and Functional Characterization ofInternational journal of molecular sciences · 2023Article
- Vesicle trafficking in rice: too little is known.Frontiers in plant science · 2023Review
- WRKY transcription factors: a promising way to deal with arsenic stress in rice.Molecular biology reports · 2022Review
- The cell biology of charophytes: Exploring the past and models for the future.Plant physiology · 2022Article
- Rice Lesion Mimic Gene Cloning and Association Analysis for Disease Resistance.Current issues in molecular biology · 2022Review
- A conserved clathrin-coated vesicle component, OsSCYL2, regulates plant innate immunity in rice.Plant, cell & environment · 2022Article
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Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clathrin-mediated vesicle trafficking (CMVT) is a fundamental process in all eukaryotic species, and indispensable to organism's growth and development. Recently, it has been suggested that CMVT also plays important roles in the regulation of plant immunity. However, the molecular link between CMVT and plant immunity is largely unknown. SCY1-LIKE2 (SCYL2) is evolutionally conserved among the eukaryote species. Loss-of-function of SCYL2 in Arabidopsis led to severe growth defects. Here, we show that mutation of OsSCYL2 in rice gave rise to a novel phenotype-hypersensitive response-like (HR) cell death in a light-dependent manner. Although mutants of OsSCYL2 showed additional defects in the photosynthetic system, they exhibited enhanced resistance to bacterial pathogens. Subcellular localisation showed that OsSCYL2 localized at Golgi, trans-Golgi network and prevacuolar compartment. OsSCYL2 interacted with OsSPL28, subunit of a clathrin-associated adaptor protein that is known to regulate HR-like cell death in rice. We further showed that OsSCYL2-OsSPL28 interaction is mediated by OsCHC1. Collectively, we characterized a novel component of the CMVT pathway in the regulation of plant immunity. Our work also revealed unidentified new functions of the very conserved SCYL2. It thus may provide new breeding targets to achieve both high yield and enhanced resistance in crops.
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