Evidence map›Paper›PMID 34866167›Full record

ArticleMikrochimica acta2021

Complete experimental and theoretical characterization of nonlinear concentration gradient generator microfluidic device for analytical purposes.

Paulo Henrique Maciel Buzzetti, Maiara Mitiko Taniguchi, Nayara de Souza Mendes, Renata Corrêa Vicentino, Jean Halison de Oliveira, Bento Pereira Cabral Júnior, Marcos de Souza, Johny Paulo Monteiro, Emerson Marcelo Girotto

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Article in Mikrochimica acta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paulo Henrique Maciel BuzzettiMaterials Chemistry and Sensors Laboratories (LMSEN), Department of Chemistry, State University of Maringá, Colombo 5790, Maringá, PR, 87020-900, Brazil.ORCID http://orcid.org/0000-0003-1074-054X
Maiara Mitiko TaniguchiMaterials Chemistry and Sensors Laboratories (LMSEN), Department of Chemistry, State University of Maringá, Colombo 5790, Maringá, PR, 87020-900, Brazil.ORCID http://orcid.org/0000-0003-0098-8031
Nayara de Souza MendesMaterials Chemistry and Sensors Laboratories (LMSEN), Department of Chemistry, State University of Maringá, Colombo 5790, Maringá, PR, 87020-900, Brazil.ORCID http://orcid.org/0000-0003-1116-6332
Renata Corrêa VicentinoDepartment of Chemical Engineering, State University of Maringá, Colombo 5790, Maringá, PR, 87020-900, Brazil.ORCID http://orcid.org/0000-0003-0386-5432
Jean Halison de OliveiraMaterials Chemistry and Sensors Laboratories (LMSEN), Department of Chemistry, State University of Maringá, Colombo 5790, Maringá, PR, 87020-900, Brazil.ORCID http://orcid.org/0000-0001-7408-6503
Bento Pereira Cabral JúniorMaterials Chemistry and Sensors Laboratories (LMSEN), Department of Chemistry, State University of Maringá, Colombo 5790, Maringá, PR, 87020-900, Brazil.ORCID http://orcid.org/0000-0002-5722-0720
Marcos de SouzaDepartment of Chemical Engineering, State University of Maringá, Colombo 5790, Maringá, PR, 87020-900, Brazil.ORCID http://orcid.org/0000-0001-5903-5396
Johny Paulo MonteiroDepartment of Chemistry, Federal University of Technologic - Paraná, Marcílio Dias 635, Apucarana, PR, 86812-460, Brazil.ORCID http://orcid.org/0000-0001-7402-2163
Emerson Marcelo GirottoMaterials Chemistry and Sensors Laboratories (LMSEN), Department of Chemistry, State University of Maringá, Colombo 5790, Maringá, PR, 87020-900, Brazil. emgirotto@uem.br.ORCID http://orcid.org/0000-0001-8723-1108

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microfluidic devices that generate stable concentration gradients are efficient instruments for automated calibration for analytical and bioanalytical systems. However, little attention has been paid to the development of reusable microfluidic concentration gradient generators, which can be useful for a range of species through mathematical characterization. In this work, we develop a microfluidic device based on three steps of serial dilution that were able to generate nonlinear concentration gradient for dyes and biomolecules. The microfluidic device was described mathematically, statistically and was suitable for reusable analytical and bioanalytical analysis. The device reproducibility was assessed by experimental tests, which have shown the same gradient concentration profile for different dyes and statistical reproducibility with 95% confidence interval for bovine serum albumin (BSA). Moreover, the experimental data converged well with those  obtained by computational fluid dynamics simulation. Applicability was verified by coupling the microfluidic device to a surface plasmon resonance (SPR) biosensor, based on nanohole arrays with sensitivity of 358.7 nm RIU

Indexed as

Automated calibrationGradient generatorMicrofluidic devicesNanohole arraysOptical biosensorSPR

Identifiers

PMID34866167

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Registered trials

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