Evidence map›Paper›PMID 34866044›Full record

ArticleMolecular cancer therapeutics2022

Abdominopelvic FLASH Irradiation Improves PD-1 Immune Checkpoint Inhibition in Preclinical Models of Ovarian Cancer.

Joshua T Eggold, Stephanie Chow, Stavros Melemenidis, Jinghui Wang, Suchitra Natarajan, Phoebe E Loo, Rakesh Manjappa, Vignesh Viswanathan, Elizabeth A Kidd, Edgar Engleman and 3 more

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Timing matters: how mechanism-guided sequencing shapes the efficacy of radiotherapy-immunotherapy combinations : A systematic review.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Review
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  11. Investigating the oxygen dependence of FLASH-RT using electron paramagnetic resonance imaging.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2026
    Article
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  15. Article
  16. Microenvironmental remodeling in FLASH radiotherapy.Frontiers in cell and developmental biology · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Joshua T Eggold *Department of Radiation Oncology, Stanford University, Stanford, California.
Stephanie Chow *Department of Gynecologic Oncology, Stanford University, Stanford, California.
Stavros MelemenidisDepartment of Radiation Oncology, Stanford University, Stanford, California.ORCID 0000-0002-3941-8784
Jinghui WangDepartment of Radiation Oncology, Stanford University, Stanford, California.
Suchitra NatarajanDepartment of Radiation Oncology, Stanford University, Stanford, California.
Phoebe E LooDepartment of Radiation Oncology, Stanford University, Stanford, California.
Rakesh ManjappaDepartment of Radiation Oncology, Stanford University, Stanford, California.ORCID 0000-0001-9681-9210
Vignesh ViswanathanDepartment of Radiation Oncology, Stanford University, Stanford, California.ORCID 0000-0001-8307-9508
Elizabeth A KiddDepartment of Radiation Oncology, Stanford University, Stanford, California.
Edgar EnglemanDepartment of Pathology, Stanford University, Stanford, California.
Oliver DorigoDepartment of Gynecologic Oncology, Stanford University, Stanford, California.
Billy W LooDepartment of Radiation Oncology, Stanford University, Stanford, California.ORCID 0000-0002-2521-0544
Erinn B RankinDepartment of Radiation Oncology, Stanford University, Stanford, California. erankin@stanford.edu.
Stanford Medicine · USStanford University · US

Funding

Effects of FLASH Radiation on Cancer and the Immune ResponseR01CA233958 · NCI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G., LOO, BILLY W · 2019 to 2024
$2.7M
NCI NIH HHS R01 CA233958
6 · The paper itself

Abstract

Treatment of advanced ovarian cancer using PD-1/PD-L1 immune checkpoint blockade shows promise; however, current clinical trials are limited by modest response rates. Radiotherapy has been shown to synergize with PD-1/PD-L1 blockade in some cancers but has not been utilized in advanced ovarian cancer due to toxicity associated with conventional abdominopelvic irradiation. Ultrahigh-dose rate (FLASH) irradiation has emerged as a strategy to reduce radiation-induced toxicity, however, the immunomodulatory properties of FLASH irradiation remain unknown. Here, we demonstrate that single high-dose abdominopelvic FLASH irradiation promoted intestinal regeneration and maintained tumor control in a preclinical mouse model of ovarian cancer. Reduced tumor burden in conventional and FLASH-treated mice was associated with an early decrease in intratumoral regulatory T cells and a late increase in cytolytic CD8

Indexed as

Ovarian NeoplasmsProgrammed Cell Death 1 ReceptorAnimalsCD8-Positive T-LymphocytesCell Line, TumorImmune Checkpoint InhibitorsMiceImmune Checkpoint InhibitorsProgrammed Cell Death 1 Receptor

Identifiers

PMID34866044
PMCPMC9229218
OpenAlexW4200505889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.