Evidence map›Paper›PMID 34866025›Full record

SynthesisInternational orthodontics2022

The adjunctive effect of autologous platelet concentrates on orthodontic tooth movement: A systematic review and meta-analysis of current randomized controlled trials.

Nima Farshidfar, Mohammad Amin Amiri, Parsa Firoozi, Shahram Hamedani, Shabnam Ajami, Lobat Tayebi

Registry-linked trialOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International orthodontics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05766618 (The Effect of Multiple Injections of Platelets Rich Fibrin), which is not on this map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05766618 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Multiple Injections of Platelets Rich Fibrin (i-PRF) on The Rate of Canine Retraction A Split-mouth: A Randomized Controlled Trial

TypeinterventionalSponsorCairo UniversityRan2023 to 2024Enrolled22ConditionsPlatelet-Rich Fibrin, Acceleration, OrthodonticsArmsInjectable platelet rich fibrin (i-PRF): in acceleration of orthodontic tooth movement
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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  9. PRF and PRP in Dentistry: An Umbrella Review.Journal of clinical medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nima FarshidfarOrthodontic Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: n.farshidfar@icloud.com.
Mohammad Amin AmiriStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mamiri1378@yahoo.com.
Parsa FirooziDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran; Student Research Committee, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran. Electronic address: parsafir2@gmail.com.
Shahram HamedaniOral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: shahramhamedani@yahoo.com.
Shabnam AjamiOrthodontic Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: dr.ajami.sh@gmail.com.
Lobat TayebiMarquette University School of Dentistry, Milwaukee, WI, USA. Electronic address: lobat.tayebi@marquette.edu.
Shiraz University of Medical Sciences · IRMarquette University · USZanjan University of Medical Sciences · IR

Funding

Supplement: Development of an Integrated 3D Human Osteo-Mucosal ModelR15DE027533 · NIDCR · MARQUETTE UNIVERSITY · PI TAYEBI, LOBAT · 2018 to 2021
$816k
Vascularization of critical-sized craniomaxillofacial defectsR56DE029191 · NIDCR · MARQUETTE UNIVERSITY · PI TAYEBI, LOBAT · 2021 to 2021
$363k
NIDCR NIH HHS R15 DE027533NIDCR NIH HHS R56 DE029191
6 · The paper itself

Abstract

objectiveTo evaluate the effectiveness of autologous platelet concentrates (APCs) as adjuncts on accelerating orthodontic tooth movement (OTM) of the human subjects undergoing orthodontic treatment and to critically appraise the available literature. METHODS AND MATERIALS: Five electronic databases (PubMed, Scopus, Web of Science, Embase, and Cochrane Central Register of Controlled Trials) were searched from 2000 up to May 2021 to retrieve eligible randomized controlled trials (RCTs) investigating patients who underwent orthodontic treatment that involved OTM of maxillary and mandibular incisors and canines. All the enrolled cases were treated with APCs and had no local or systemic interfering factors. The quality of the included studies was assessed using the modified JADAD scale. The effect sizes were assessed using mean difference (MD). The heterogeneity analysis was conducted using (I

resultsFinally, seven RCTs were included in the qualitative, and two RCTs were included in the quantitative analysis. The meta-analysis was performed regarding the effect of injectable platelet-rich fibrin (I-PRF) on the rate of canine tooth movement in millimeters at different intervals of the 1

conclusionsAccording to the low certainty of evidence about this topic, providing a definite conclusion is not possible. However, applying I-PRF seems to be efficient in accelerating the OTM of the canines. Further high-quality studies with larger sample sizes will be indispensable to validate this conclusion.

Indexed as

Platelet-Rich FibrinTooth Movement TechniquesCuspidHumansIncisorRandomized Controlled Trials as TopicPlatelet-rich FibrinPlatelet-rich PlasmaPRFPRPTooth Movement Techniques

Identifiers

PMID34866025
PMCPMC8860857
OpenAlexW4200338959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.