ArticleBiological psychiatry2022
Posttraumatic Stress Disorder, Myocardial Perfusion, and Myocardial Blood Flow: A Longitudinal Twin Study.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records.Molecular psychiatry · 2022Pooled it
- Association of Type D Personality and Anatomical Complexity as Predictors of Long-Term Mortality in Coronary Artery Disease: A Retrospective Case Study Based on Hospital Records.Diseases (Basel, Switzerland) · 2026Article
- Lack of relationship between posttraumatic stress disorder and coronary atherosclerotic burden among twin veterans from the Vietnam era.American journal of epidemiology · 2026Article
- Zygosity and autonomic stress reactivity during social exclusion: biofeedback findings from the TwinCord-EDID study.Frontiers in psychiatry · 2026Article
- Post-Traumatic Stress Disorder (PTSD) and Cardiovascular Diseases: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Mental health disorders and their impact on cardiovascular health disparities.The Lancet regional health. Europe · 2025Review
- Myocardial blood flow mechanism of mental stress-induced myocardial ischemia in women with ANOCA.iScience · 2024Article
- Posttraumatic Stress Disorder and the Risk of Heart Failure Hospitalizations Among Individuals With Coronary Artery Disease.Circulation. Cardiovascular quality and outcomes · 2024Article
- Stress and cardiovascular disease: an update.Nature reviews. Cardiology · 2024Review
- Exaggerated Peripheral and Systemic Vasoconstriction During Trauma Recall in Posttraumatic Stress Disorder: A Co-Twin Control Study.Biological psychiatry · 2024Article
- Quantifying Posttraumatic Stress Disorder Symptoms During Traumatic Memories Using Interpretable Markers of Respiratory Variability.IEEE journal of biomedical and health informatics · 2024Article
- Posttraumatic Stress Disorder and Obstructive Sleep Apnea in Twins.JAMA network open · 2024Article
- Heart-brain axis: Pushing the boundaries of cardiovascular molecular imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Review
- Impedance cardiogram based exploration of cardiac mechanisms in post-traumatic stress disorder during trauma recall.Psychophysiology · 2024Article
- Association between PTSD and Impedance Cardiogram-based contractility metrics during trauma recall: A controlled twin study.Psychophysiology · 2023Article
- Association of Autonomic Activation with traumatic reminder challenges in posttraumatic stress disorder: A co-twin control study.Psychophysiology · 2023Article
- Clinical Evaluation Tool for Vascular Health-Endothelial Function and Cardiovascular Disease Management.Cells · 2022Review
- Obstructive sleep apnea, myocardial perfusion and myocardial blood flow: A study of older male twins.PloS one · 2022Article
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Authors and funding
23 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe link between posttraumatic stress disorder (PTSD) and ischemic heart disease remains elusive owing to a shortage of longitudinal studies with a clinical diagnosis of PTSD and objective measures of cardiac compromise.
methodsWe performed positron emission tomography in 275 twins who participated in two examinations approximately 12 years apart. At both visits, we obtained a clinical diagnosis of PTSD, which was classified as long-standing (both visit 1 and visit 2), late onset (only visit 2), and no PTSD (no PTSD at both visits). With positron emission tomography, we assessed myocardial flow reserve (MFR), which, in absence of significant coronary stenoses, indexes coronary microvascular function. We compared positron emission tomography data at visit 2 across the three categories of longitudinally assessed PTSD and examined changes between the two visits.
resultsOverall, 80% of the twins had no or minimal obstructive coronary disease. Yet, MFR was depressed in twins with PTSD and was progressively lower across groups with no PTSD (2.13), late-onset PTSD (1.97), and long-standing PTSD (1.93) (p = .01). A low MFR (a ratio <2.0) was present in 40% of the twins without PTSD, in 56% of those with late-onset PTSD, and in 72% of those with long-standing PTSD (p < .001). Associations persisted in multivariable analysis, when examining changes in MFR between visit 1 and visit 2, and within twin pairs. Results were similar by zygosity.
conclusionsLongitudinally, PTSD is associated with reduced coronary microcirculatory function and greater deterioration over time. The association is especially noted among twins with chronic, long-standing PTSD and is not confounded by shared environmental or genetic factors.
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