ArticleInternational journal of retina and vitreous2021
Early neurovascular retinal changes detected by swept-source OCT in type 2 diabetes and association with diabetic kidney disease.
Article in International journal of retina and vitreous, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Can continuous glucose monitoring-derived glycemic variability predict retinal neurodegeneration earlier than HbA1c in patients without clinically apparent retinopathy?Frontiers in endocrinology · 2026Review
- Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease: a longitudinal prospective study.BMC ophthalmology · 2024Article
- Retinal neurovascular alteration in type 2 diabetes with renal impairment in association with systemic arterial stiffness.International journal of retina and vitreous · 2024Article
- Deep learning in optical coherence tomography: Where are the gaps?Clinical & experimental ophthalmology · 2023Review
- Early retinal neurovascular findings in post-transplant diabetes mellitus patients without clinical signs of diabetic retinopathy.International journal of retina and vitreous · 2023Article
- Association of advanced chronic kidney disease with diabetic retinopathy severity in older patients with diabetes: a retrospective cross-sectional study.Journal of Yeungnam medical science · 2023Article
- Article
- Early choroidal changes detected by swept-source OCT in type 2 diabetes and their association with diabetic kidney disease.BMJ open diabetes research & care · 2022Article
- Optical Coherence Tomography Angiography in Type 1 Diabetes Mellitus-Report 2: Diabetic Kidney Disease.Journal of clinical medicine · 2021Article
- Optical coherence tomography and optical coherence tomography angiography in systemic disease.Taiwan journal of ophthalmologyReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate retinal thickness and capillary density in patients with type 2 diabetes (T2D) and their association with diabetic kidney disease (DKD) using swept-source optical coherence tomography (SS-OCT).
methodsA cross-sectional study was conducted with T2D patients with mild or no diabetic retinopathy (DR) and nondiabetic controls. Inner retinal layer thickness was measured with SS-OCT. Retinal capillary density and the foveal avascular zone (FAZ) were measured with SS-OCT angiography (OCTA). SS-OCT parameters were compared in patients with and without diabetic kidney disease (DKD) and nondiabetic controls.
results131 DKD eyes showed decreased ganglion cell layer plus (GCL+) (p = 0.005 TI; p = 0.022 I), retinal nerve fiber layer (RNFL) (p = 0.003), and central retinal thickness (CRT) (p = 0.032), as well as foveal avascular zone (FAZ) enlargement (p = 0.003) and lower capillary density in the superficial vascular plexus (p = 0.016, central quadrant), compared to controls. No statistically significant changes were found between diabetic patients without significant DKD and controls.
conclusionOur findings suggest early neurovascular damage in patients with T2D; these changes were more significant in patients with DKD. Larger longitudinal studies are warranted to determine the role of early neurovascular damage in the pathophysiology of severe DR.
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