ArticlePerioperative medicine (London, England)2021
High-flow nasal oxygenation reduces the risk of desaturation in adults receiving procedural sedation: a meta-analysis of randomized controlled trials.
Article in Perioperative medicine (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Effect of high-flow nasal oxygen on hypoxaemia during procedural sedation: a systematic review and meta-analysis.Anaesthesia · 2023Pooled it
- Effectiveness of High-Flow Nasal Oxygen vs. Standard Nasal Oxygen in Preventing Hypoxia During Procedural Sedation in Minor and Moderate Burn Patients: A Prospective Observational Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Clinical feasibility of high-flow nasal oxygenation during dental procedures in pediatric patients under intravenous deep sedation: initial experience.BMC oral health · 2026Article
- The Effect of Deep Sedation with High Flow Nasal Oxygen Therapy on the Transcutaneous COSensors (Basel, Switzerland) · 2025Observational
- High-flow Nasal Cannula versus Conventional Ventilation in Laryngeal Surgery: A Systematic Review and Meta-analysis.Cureus · 2023Review
- Comparative efficacy of high-flow nasal cannula versus conventional oxygen delivery during procedural sedation for ovum pickup in assisted reproductive technology.Saudi journal of anaesthesiaArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundProcedural sedation reduces patients' discomfort and anxiety, facilitating performance of the examination and intervention. However, it may also cause adverse events, including airway obstruction and hypoxia. We conducted this systematic review and meta-analysis to evaluate the efficacy of high-flow nasal oxygenation (HFNO) compared with that of standard oxygen therapy in adult patients undergoing procedural sedation.
methodsWe identified randomized controlled trials published before November 2020 based on PubMed, Embase, and Cochrane Library databases and ClinicalTrials.gov registry. Intraprocedural desaturation [peripheral oxygen saturation (SpO
resultsSix trials with a total of 2633 patients were reviewed. Patients using HFNO compared with standard oxygen therapy had a significantly lower risk of intraprocedural desaturation [risk ratio 0.18, 95% confidence interval (CI) 0.04-0.87]. The lowest intraprocedural SpO
conclusionsCompared with standard oxygen therapy, HFNO may reduce the risk of desaturation and increase the lowest SpO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.