Evidence map›Paper›PMID 34865302›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2022

Trends and outcomes for deliveries with hypertensive disorders of pregnancy from 2000 to 2018: A repeated cross-sectional study.

Timothy Wen, Christina N Schmidt, Nasim C Sobhani, Jean Guglielminotti, Eliza C Miller, Desmond Sutton, Yael Lahtermaher, Mary E D'Alton, Alexander M Friedman

Open access · greenAbstract read
In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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  9. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024
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  10. Preeclampsia and HELLP syndrome complicated by subcapsular liver hematoma and rupture.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Timothy WenDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-1749-3142
Christina N SchmidtUniversity of California San Francisco School of Medicine, San Francisco, California, USA.
Nasim C SobhaniDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-2856-3185
Jean GuglielminottiDepartment of Anesthesiology, Columbia University Irving Medical Center, New York, New York, USA.
Eliza C MillerDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Desmond SuttonDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York, USA.
Yael LahtermaherEscola de Medicina Souza Marques (EMSM), Fundação Tecnico Educação Souza Marques, Rio De Janeiro, Brazil.
Mary E D'AltonDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York, USA.
Alexander M FriedmanDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York, USA.
Columbia University Irving Medical Center · USUniversity of California, San Francisco · USColumbia University · USFundação Técnico Educacional Souza Marques · BR

Funding

Neurovascular Unit Dysfunction in Women with Severe PreeclampsiaK23NS107645 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MILLER, ELIZA C · 2019 to 2023
$1.1M
MerckNINDS NIH HHS K23 NS107645
6 · The paper itself

Abstract

objectiveTo analyse trends, risk factors, and outcomes related to hypertensive disorders of pregnancy (HDP).

designRepeated cross-sectional.

settingUS delivery hospitalisations. POPULATION: Delivery hospitalisations in the 2000-2018 National Inpatient Sample.

methodsUS hospital delivery hospitalisations with HDP were analysed. Several trends were analysed: (i) the proportion of deliveries by year with HDP, (ii) the proportion of deliveries with HDP risk factors and (iii) adverse outcomes associated with HDP including maternal stroke, acute renal failure and acute liver injury. Risk ratios were determined using regression models with HDP as the exposure of interest.

main outcome measuresPrevalence of HDP, risk factors for HDP and associated adverse outcomes.

resultsOf 73.1 million delivery hospitalisations, 7.7% had an associated diagnosis of HDP. Over the study period, HDP doubled from 6.0% of deliveries in 2000 to 12.0% in 2018. The proportion of deliveries with risk factors for HDP increased from 9.6% in 2000 to 24.6% in 2018. In adjusted models, HDP were associated with increased stroke (aRR [adjusted risk ratio] 15.9, 95% CI 14.8-17.1), acute renal failure (aRR 13.8, 95% CI 13.5-14.2) and acute liver injury (aRR 1.2, 95% CI 1.2-1.3). Among deliveries with HDP, acute renal failure and acute liver injury increased; in comparison, stroke decreased.

conclusionHypertensive disorders of pregnancy increased in the setting of risk factors for HDP becoming more common, whereas stroke decreased. TWEETABLE ABSTRACT: While hypertensive disorders of pregnancy increased from 2000 to 2018, stroke appears to be decreasing.

Indexed as

Acute Kidney InjuryHypertension, Pregnancy-InducedPre-EclampsiaStrokeCross-Sectional StudiesFemaleHumansPregnancyPrevalencehypertensive disorders of pregnancymaternal safetypre-eclampsiasevere maternal morbidity

Identifiers

PMID34865302
PMCPMC10028501
OpenAlexW4200519326

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.