ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2022
Alcohol and Vaporized Nicotine Co-exposure During Adolescence Contribute Differentially to Sex-Specific Behavioral Effects in Adulthood.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Impact of flavorants on nicotine vapor self-administration in adolescent mice: Cherry on top?The Journal of pharmacology and experimental therapeutics · 2025Article
- A case against purity: prioritizing translational polysubstance use research.Current opinion in psychiatry · 2025Review
- Dynorphinergic lateral hypothalamus to posterior ventral tegmental area pathway matures after adolescence in male rats.Neuropharmacology · 2025Article
- Rats chasing the dragon: A new heroin inhalation method.Journal of neuroscience methods · 2024Article
- Sex Differences in E-Cigarette Use and Related Health Effects.International journal of environmental research and public health · 2023Review
- Consequences of adolescent drug use.Translational psychiatry · 2023Review
- Nicotinic and muscarinic acetylcholine receptor antagonism dose-dependently decreases sign- but not goal-tracking behavior in male rats.Psychopharmacology · 2023Article
- Adolescent alcohol and nicotine exposure alters the adult response to alcohol use.Advances in drug and alcohol research · 2023Review
- The effects of electronic nicotine vapor on voluntary alcohol consumption in female and male C57BL/6 J mice.Drug and alcohol dependence · 2022Article
- The Unhealthy Association Between Smoking, Vaping, and Other Drug Use.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Article
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- Sex Differences in the Behavioural Outcomes of Prenatal Nicotine and Tobacco Exposure.Frontiers in neuroscience · 2022Review
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Authors and funding
5 authors.
Funding
Abstract
introductionCo-occurrence of e-cigarette use and alcohol consumption during adolescence is frequent. Here, we examined whether adolescent co-exposure to alcohol drinking and vaporized nicotine would impact reward- and cognition-related behaviors in adult male and female rats during adulthood. AIMS AND
methodsFour groups of male and female Sprague Dawley rats (n = 8-11/group/sex) received either nicotine (JUUL 5% nicotine pods) or vehicle vapor for 10 minutes daily between postnatal days 30-46, while having continuous voluntary access to ethanol and water during this time in a two-bottle preference design. Upon reaching adulthood, all rats underwent behavioral testing (ie, Pavlovian conditioned approach testing, fear conditioning and a two-bottle alcohol preference).
resultsA sex-dependent effect, not related to adolescent nicotine or alcohol exposure, on alcohol drinking in adulthood was found, such that females had a higher intake and preference for alcohol compared to males; both male and female adult rats also had greater alcohol preference compared to their alcohol preference as adolescents. Male rats exposed to vaporized nicotine with or without alcohol drinking during adolescence exhibited altered reward-related learning in adulthood, evidenced by enhanced levels of sign-tracking behavior. Male rats that drank alcohol with or without nicotine vapor in adolescence showed deficits in associative fear learning and memory as adults. In contrast, these effects were not seen in female rats exposed to alcohol and nicotine vapor during adolescence.
conclusionsThe present study provides evidence that co-exposure to alcohol and vaporized nicotine during adolescence in male, but not female, rats produces long-term changes in reward- and cognition-related behaviors. IMPLICATIONS: These findings enhance our understanding of the effects of alcohol drinking and nicotine vapor exposure in adolescence. Moreover, they highlight potential sex differences that exist in the response to alcohol and nicotine vapor, underscoring the need for follow-up studies elucidating the neurobiological mechanisms that drive these sex differences, as well as the long-term effects of alcohol and nicotine vapor use.
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