Evidence map›Paper›PMID 34865043›Full record

ArticleInternational journal of epidemiology2022

Quantifying the contribution of pathways of nosocomial acquisition of COVID-19 in English hospitals.

Stephanie Evans, James Stimson, Diane Pople, Alex Bhattacharya, Russell Hope, Peter J White, Julie V Robotham

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 46 citations in OpenAlex.

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  8. Randomized trial of the safety and efficacy of anti-SARS-CoV-2 mAb in the treatment of patients with nosocomial COVID-19 (CATCO-NOS).Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stephanie EvansHCAI, Fungal, AMR, AMU & Sepsis Division, UK Health Security Agency, London, UK.ORCID 0000-0002-2345-5249
James StimsonHCAI, Fungal, AMR, AMU & Sepsis Division, UK Health Security Agency, London, UK.
Diane PopleHCAI, Fungal, AMR, AMU & Sepsis Division, UK Health Security Agency, London, UK.
Alex BhattacharyaOutbreak Surveillance Team, UK Health Security Agency, London, UK.
Russell HopeHCAI, Fungal, AMR, AMU & Sepsis Division, UK Health Security Agency, London, UK.ORCID 0000-0003-2838-6833
Peter J WhiteStatistics, Modelling and Economics, UK Health Security Agency, London, UK.
Julie V RobothamHCAI, Fungal, AMR, AMU & Sepsis Division, UK Health Security Agency, London, UK.
UK Health Security Agency · GBUniversity of Oxford · GB

Funding

Medical Research Council MC_PC_19012Medical Research Council MR/R015600/1
6 · The paper itself

Abstract

backgroundDespite evidence of the nosocomial transmission of novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in hospitals worldwide, the contributions of the pathways of transmission are poorly quantified.

methodsWe analysed national records of hospital admissions and discharges, linked to data on SARS-CoV-2 testing, using an individual-based model that considers patient-to-patient, patient-to-healthcare worker (HCW), HCW-to-patient and HCW-to-HCW transmission.

resultsBetween 1 March 2020 and 31 December 2020, SARS-CoV-2 infections that were classified as nosocomial were identified in 0.5% (0.34-0.74) of patients admitted to an acute National Health Service trust. We found that the most likely route of nosocomial transmission to patients was indirect transmission from other infected patients, e.g. through HCWs acting as vectors or contaminated fomites, followed by direct transmission between patients in the same bay. The risk of transmission to patients from HCWs over this time period is low, but can contribute significantly when the number of infected inpatients is low. Further, the risk of a HCW acquiring SARS-CoV-2 in hospital is approximately equal to that in the community, thereby doubling their overall risk of infection. The most likely route of transmission to HCWs is transmission from other infected HCWs.

conclusionsCurrent control strategies have successfully reduced the transmission of SARS-CoV-2 between patients and HCWs. In order to reduce the burden of nosocomial COVID-19 infections on health services, stricter measures should be enforced that would inhibit the spread of the virus between bays or wards in the hospital. There should also be a focus on inhibiting the spread of SARS-CoV-2 between HCWs. The findings have important implications for infection-control procedures in hospitals.

Indexed as

COVID-19Cross InfectionCOVID-19 TestingHealth PersonnelHospitalsHumansSARS-CoV-2State Medicinehealthcare-acquired infectionhealthcare workerspatientsSARS-CoV-2transmission

Identifiers

PMID34865043
PMCPMC8690325
OpenAlexW4200397999

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.