ArticleTranslational psychiatry2021
Association of low-frequency and rare coding variants with information processing speed.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Rare genetic variants correlate with better processing speed.Neurobiology of aging · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
55 authors at 20 institutions in 7 countries.
Jan Bressler *Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA. jan.bressler@uth.tmc.edu.ORCID http://orcid.org/0000-0001-6578-4772
Gail Davies *Lothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1120-7026
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Yasaman SabaGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Xueqiu JianBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Lisa YanekDepartment of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7117-1075
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
Saira S MirzaDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Ruiqi WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Hieab H H AdamsDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-3687-2508
Diane BeckerDepartment of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Simon R CoxLothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4036-3642
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Chloe Fawns-RitchieLothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Rebecca F GottesmanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9504-1256
Megan L GroveHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6764-2508
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Maria J KnolDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3597-1531
Marisa KoiniClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Oscar L LopezDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-8546-8256
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Paul NyquistDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alison PattieLothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.
Ozren PolasekFaculty of Medicine, University of Split, Split, Croatia.
David J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Igor RudanCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Claudia L SatizabalFramingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0002-1115-4430
Helena SchmidtGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Stephen SidneyKaiser Permanente Northern California Division of Research, Oakland, CA, USA.
Jeannette SiminoDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Blair H SmithDivision of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0002-5362-9430
Stephen T TurnerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Sven J van der LeeDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1606-8643
Erin B WareSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Rachel A WhitmerKaiser Permanente Northern California Division of Research, Oakland, CA, USA.
Kristine YaffeDepartment of Psychiatry, University of California San Francisco, San Francisco, CA, USA.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7388-0692
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Lenore J LaunerLaboratory of Epidemiology and Population Science, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3238-7612
Annette L FitzpatrickDepartment of Family Medicine, University of Washington, Seattle, WA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Sudha SeshadriFramingham Heart Study, Framingham, MA, USA.
Thomas H MosleyDivision of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Ian J DearyLothian Birth Cohorts, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1733-263X
Erasmus MC · NLMedical University of Graz · ATNHS Lothian · GBBoston University · USEdinburgh Cancer Research · GBJohns Hopkins University · USUniversity of Michigan · USUniversity of Washington · USBrown Foundation · USIcelandic Heart Association · ISKaiser Permanente · USThe University of Texas Health Science Center at Houston · USBaylor College of Medicine · USJackson Memorial Hospital · USMayo Clinic · USNational Institutes of Health · USSunnybrook Health Science Centre · CAUCLA Medical Center · USUniversity of California, San Francisco · USUniversity of Dundee · GB
Funding
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MCollaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesR01AG033193 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SESHADRI, SUDHA · 2009 to 2016
$4.4MLifecourse CVD Risk and Midlife Cognitive Trajectories and Brain Aging: Implications for Alzheimer's and Dementia PreventionR01AG063887 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI YAFFE, KRISTINE · 2019 to 2022
$3.0MOccult Small Vessel Cerebrovascular Disease in High Risk FamiliesR01NS062059 · NINDS · JOHNS HOPKINS UNIVERSITY · PI NYQUIST, PAUL ALAN · 2009 to 2013
$3.0MDeterminants of Midlife & Longitudinal Change in Cognitive Function: CARDIA StudyR01HL122658 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI SIDNEY, STEPHEN, YAFFE, KRISTINE · 2015 to 2018
$3.0MAn Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel DiseaseR01NS087541 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A., FORNAGE, MYRIAM · 2014 to 2017
$2.5MA Genome-Wide Association Study of Ischemic Brain Vascular InjuryR01HL093029 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FORNAGE, MYRIAM · 2009 to 2010
$1.6MGWAS of longitudinal blood pressure profiles from young adulthood to middle-ageU01HG004729 · NHGRI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FORNAGE, MYRIAM · 2008 to 2009
$1.1MMedical Research Council G0700704Medical Research Council MC_UU_00007/10Medical Research Council MR/K026992/1NHGRI NIH HHS U01 HG004729NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL105756NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG063887NINDS NIH HHS R01 NS087541
Abstract
Measures of information processing speed vary between individuals and decline with age. Studies of aging twins suggest heritability may be as high as 67%. The Illumina HumanExome Bead Chip genotyping array was used to examine the association of rare coding variants with performance on the Digit-Symbol Substitution Test (DSST) in community-dwelling adults participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. DSST scores were available for 30,576 individuals of European ancestry from nine cohorts and for 5758 individuals of African ancestry from four cohorts who were older than 45 years and free of dementia and clinical stroke. Linear regression models adjusted for age and gender were used for analysis of single genetic variants, and the T5, T1, and T01 burden tests that aggregate the number of rare alleles by gene were also applied. Secondary analyses included further adjustment for education. Meta-analyses to combine cohort-specific results were carried out separately for each ancestry group. Variants in RNF19A reached the threshold for statistical significance (p = 2.01 × 10
Indexed as
Genome-Wide Association StudyGeroscienceAdultAgingCognitionHumansPolymorphism, Single NucleotideUbiquitin-Protein LigasesRNF19A protein, humanUbiquitin-Protein Ligases
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