Evidence map›Paper›PMID 34864576›Full record

ArticleCancer epidemiology2022

The risk of childhood brain tumors associated with delivery interventions: A Danish matched case-control study.

Karen W Yeh, Di He, Johnni Hansen, Catherine L Carpenter, Beate Ritz, Jorn Olsen, Julia E Heck

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Karen W YehDepartment of Epidemiology, Fielding School of Public Health, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: karenwyeh@g.ucla.edu.
Di HeDepartment of Epidemiology, Fielding School of Public Health, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: dihe7@ucla.edu.
Johnni HansenDanish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark. Electronic address: johnni@cancer.dk.
Catherine L CarpenterDepartment of Epidemiology, Fielding School of Public Health, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: ccarpenter@mednet.ucla.edu.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: britz@ucla.edu.
Jorn OlsenDepartment of Clinical Epidemiology, Aarhus University, Olof Palmes Alle 43-45, 8200 Aarhus N Aarhus, Denmark. Electronic address: jo@ph.au.dk.
Julia E HeckDepartment of Epidemiology, Fielding School of Public Health, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; College of Health and Public Service, University of North Texas, 1155 Union Circle, Denton, TX, 76203, USA. Electronic address: julia.heck@unt.edu.
Fielding Graduate University · USAarhus University · DKDanish Cancer Society · DKUniversity of North Texas · US

Funding

Maternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015
$323k
Parental Occupation and Childhood CancersR03ES021643 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2012 to 2013
$152k
NCI NIH HHS R21 CA175959NIEHS NIH HHS R03 ES021643
6 · The paper itself

Abstract

backgroundHead trauma has been associated with increased brain tumor risk in adults. Instrument assisted delivery can be a cause of head trauma in newborns. The goal of this study was to determine if instrument-assisted deliveries influenced the odds of childhood brain tumors in Denmark.

methodsWe conducted a matched case-control study of childhood (<20 years) brain tumors in Denmark born between 1978 and 2013 and diagnosed 1978-2016. A total of 1678 brain tumor cases were identified and 25 controls were matched to each case based on the child's sex and birth date (N = 40,934). Conditional logistic regression was used to estimate effects (odds ratios (OR) and 95% confidence intervals (95%CI)) for variables of interest.

resultsCompared to children birthed by spontaneous vaginal delivery, children who later developed ependymomas (N = 118) had a greater likelihood of having experienced vacuum assisted deliveries (OR=1.74, 95% CI 1.02-2.96). Forceps use was low, and declined across the study period. We did not observe an overall increase in all CNS tumors (combined) with either vacuum delivery (OR=0.99, 95% CI 0.84-1.18) or forceps delivery (OR=1.26, 95% CI 0.78-2.03).

conclusionOur findings suggest an association between vacuum assisted deliveries and ependymomas.

Indexed as

Brain NeoplasmsCraniocerebral TraumaEpendymomaAdultCase-Control StudiesChildDenmarkFemaleHumansInfant, NewbornBrain neoplasmsCesarean sectionDelivery complicationsInstrument-assisted deliveryPediatric cancer epidemiology

Identifiers

PMID34864576
PMCPMC8840805
OpenAlexW4200278966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.