ArticleNeuroImage. Clinical2022
Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting.
Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Anhedonia and Delay Discounting: Differing Patterns of Brain-Behavior Relationships in Healthy Control Participants Versus Individuals With Posttraumatic Stress Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- A meta-analysis of neural systems underlying delay discounting: Implications for transdiagnostic research.Imaging neuroscience (Cambridge, Mass.)Article
- Insular glioma and emotional states affect the whole brain network: a task-state electroencephalography study.Frontiers in neurologyArticle
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Authors and funding
14 authors.
Funding
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Abstract
Previous studies have shown that the insula is closely related to addiction, and the structure's role in delay discounting can be measured by a specific task, but the specific role of the insula has been less studied. In this study, we first conducted a lesion study in which we recruited healthy controls (n = 30) and patients with unilateral insula injury (n = 16) to complete a behavioral delay discounting task. Then we conducted a functional magnetic resonance imaging (fMRI) study, and a separate group healthy volunteers (n = 51) completed a delay discounting task during the fMRI scan. The lesion study showed a significant difference between the two groups in the delay discounting task, which revealed that insula injury was associated with impaired decision making. The fMRI study revealed choice-sensitive insula activation that was modulated by delayed time and delayed reward, indicating an important role of the insula in delay discounting. Overall, our results provide evidence for a role of the insular lobe in delay discounting and suggests that this structure may be considered an important factor in the future treatment and diagnosis of addiction disorders.
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