ArticleSeizure2022
Epilepsy mortality in Wales during COVID-19.
Article in Seizure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- A prospective observational study evaluating drug-related problems and their impact on patient-related outcomes in hospitalized epileptic patients.Scientific reports · 2026Observational
- Article
- Morbidity and mortality risks associated with valproate withdrawal in young adults with epilepsy.Brain : a journal of neurology · 2024Article
- Increased frequency and mortality in persons with neurological disorders during COVID-19.Brain : a journal of neurology · 2024Article
- Mortality and mortality disparities among people with epilepsy in the United States, 2011-2021.Epilepsy & behavior : E&B · 2024Article
- Medication compliance of children with epilepsy: a cross-sectional survey.Italian journal of pediatrics · 2023Article
- Seizures in COVID-19: the relationship between biomarkers and prognosis.Acta neurologica Belgica · 2023Article
- Epilepsy-related mortality during the COVID-19 pandemic: A nationwide study of routine Scottish data.Seizure · 2023Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeThe COVID-19 pandemic has increased mortality worldwide and those with chronic conditions may have been disproportionally affected. However, it is unknown whether the pandemic has changed mortality rates for people with epilepsy. We aimed to compare mortality rates in people with epilepsy in Wales during the pandemic with pre-pandemic rates.
methodsWe performed a retrospective study using individual-level linked population-scale anonymised electronic health records. We identified deaths in people with epilepsy (DPWE), i.e. those with a diagnosis of epilepsy, and deaths associated with epilepsy (DAE), where epilepsy was recorded as a cause of death on death certificates. We compared death rates in 2020 with average rates in 2015-2019 using Poisson models to calculate death rate ratios.
resultsThere were 188 DAE and 628 DPWE in Wales in 2020 (death rates: 7.7/100,000/year and 25.7/100,000/year). The average rates for DAE and DPWE from 2015 to 2019 were 5.8/100,000/year and 23.8/100,000/year, respectively. Death rate ratios (2020 compared to 2015-2019) for DAE were 1.34 (95%CI 1.14-1.57, p<0.001) and for DPWE were 1.08 (0.99-1.17, p = 0.09). The death rate ratios for non-COVID deaths (deaths without COVID mentioned on death certificates) for DAE were 1.17 (0.99-1.39, p = 0.06) and for DPWE were 0.96 (0.87-1.05, p = 0.37).
conclusionsThe significant increase in DAE in Wales during 2020 could be explained by the direct effect of COVID-19 infection. Non-COVID-19 deaths have not increased significantly but further work is needed to assess the longer-term impact.
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