Evidence map›Paper›PMID 34864047›Full record

ArticleBiophysical journal2022

Cell-cell adhesion impacts epithelia response to substrate stiffness: Morphology and gene expression.

David Choi, Zachary Gonzalez, Sum Yat Ho, Alexandra Bermudez, Neil Y C Lin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

David ChoiDepartment of Mechanical and Aerospace Engineering, University of California, Los Angeles, California. Electronic address: choidavid713@g.ucla.edu.
Zachary GonzalezDepartment of Mechanical and Aerospace Engineering, University of California, Los Angeles, California; Department of Physics and Astronomy, University of California, Los Angeles, California.
Sum Yat HoDepartment of Mechanical and Aerospace Engineering, University of California, Los Angeles, California; Department of Chemistry and Biochemistry, University of California, Los Angeles, California.
Alexandra BermudezDepartment of Mechanical and Aerospace Engineering, University of California, Los Angeles, California; Department of Bioengineering, University of California, Los Angeles, California.
Neil Y C LinDepartment of Mechanical and Aerospace Engineering, University of California, Los Angeles, California; Department of Bioengineering, University of California, Los Angeles, California; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles.
University of California, Los Angeles · USQB3 · US

Funding

UCLA SPORE IN PROSTATE CANCERP50CA092131 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI REITER, ROBERT E · 2002 to 2023
$42.6M
UCLA MSD ProgramR25GM055052 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BARBER, PAUL HENRY, HASSON, TAMA W. · 1996 to 2021
$9.2M
NCI NIH HHS P50 CA092131NIGMS NIH HHS R25 GM055052
6 · The paper itself

Abstract

Monolayer epithelial cells interact constantly with the substrate they reside on and their surrounding neighbors. As such, the properties of epithelial cells are profoundly governed by the mechanical and molecular cues that arise from both the substrate and contiguous cell neighbors. Although both cell-substrate and cell-cell interactions have been studied individually, these results are difficult to apply to native confluent epithelia, in which both jointly regulate the cell phenotype. Specifically, it remains poorly understood about the intertwined contributions from intercellular adhesion and substrate stiffness on cell morphology and gene expression, two essential microenvironment properties. Here, by adjusting the substrate modulus and altering the intercellular adhesion within confluent kidney epithelia, we found that cell-substrate and cell-cell interactions can mask each other's influence. For example, we found that epithelial cells exhibit an elongated morphological phenotype only when the substrate modulus and intercellular adhesions are both reduced, whereas their motility can be upregulated by either reduction. These results illustrate that combinatorial changes of the physical microenvironment are required to alter cell morphology and gene expression.

Indexed as

Cell CommunicationEpithelial CellsCell AdhesionEpitheliumGene Expression

Identifiers

PMID34864047
PMCPMC8790207
OpenAlexW3215411645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.