Evidence map›Paper›PMID 34864029›Full record

ArticleThe Science of the total environment2022

Modeling complex effects of exposure to particulate matter and extreme heat during pregnancy on congenital heart defects: A U.S. population-based case-control study in the National Birth Defects Prevention Study.

Will Simmons, Shao Lin, Thomas J Luben, Scott C Sheridan, Peter H Langlois, Gary M Shaw, Jennita Reefhuis, Paul A Romitti, Marcia L Feldkamp, Wendy N Nembhard and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Science of the total environment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Will SimmonsDepartment of Epidemiology, Columbia University, 722 West 168(th) Street, NY, New York 10032, USA.
Shao LinDepartment of Epidemiology and Biostatistics, University at Albany, 1 University Place, Rensselaer, NY 12144, USA; Department of Environmental Health Sciences, University at Albany, 1 University Place, Rensselaer, NY, 12144, USA.
Thomas J LubenOffice of Research and Development, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, RTP, NC 27711, USA.
Scott C SheridanDepartment of Geography, Kent State University, 325 S. Lincoln Street, Kent, OH 44242, USA.
Peter H LangloisDepartment of Epidemiology, Human Genetics, and Environmental Science, University of Texas School of Public Health, 1616 Guadalupe Street, Austin, TX 78701, USA.
Gary M ShawStanford School of Medicine, 453 Quarry Road, Stanford, CA 94305, USA.
Jennita ReefhuisNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.
Paul A RomittiDepartment of Epidemiology, The University of Iowa, 145 N. Riverside Drive, Iowa City, IA 52242, USA.
Marcia L FeldkampDepartment of Pediatrics, University of Utah School of Medicine, 295 Chipeta Way, Salt Lake City, UT 84108, USA.
Wendy N NembhardDepartments of Pediatrics and Epidemiology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA.
Tania A DesrosiersDepartment of Epidemiology, University of North Carolina, 135 Dauer Drive, Chapel Hill, NC 27599, USA.
Marilyn L BrowneDepartment of Epidemiology and Biostatistics, University at Albany, 1 University Place, Rensselaer, NY 12144, USA; Birth Defects Registry, New York State Department of Health, Corning Tower, Empire State Plaza, Albany, NY 12237, USA.
Jeanette A StingoneDepartment of Epidemiology, Columbia University, 722 West 168(th) Street, NY, New York 10032, USA. Electronic address: j.stingone@columbia.edu.
National Birth Defects Prevention Study

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3M
Iowa CBDRP: Component A BD-STEPS II CoreU01DD001223 · DD · UNIVERSITY OF IOWA · PI CONWAY, KRISTIN, ROMITTI, PAUL A · 2018 to 2022
$4.3M
Component A: BD-STEPS II Core at North Carolina Center for Birth Defects Research and Prevention (NC BDSTEPS II Core)U01DD001231 · DD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DESROSIERS, TANIA A., OLSHAN, ANDREW · 2018 to 2022
$4.2M
New York State Component A: BD-STEPS II CoreU01DD001227 · DD · CENTER OF ENVIRONMENTAL HEALTH · PI HOWLEY, MEREDITH M · 2018 to 2022
$4.2M
Weather extremes, natural disasters, and health outcomes among vulnerable older adults: New improvements on exposure assessment, disparity identification, and risk communication strategiesR01AG070949 · NIA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI LIN, SHAO · 2022 to 2025
$1.6M
A DATA SCIENCE APPROACH TO AIR TOXICS AND CHILDREN'S ENVIRONMENTAL HEALTHR00ES027022 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STINGONE, JEANETTE A · 2018 to 2020
$742k
Assess and Model the Health Effects, Population, and Infrastructural Vulnerabilities of Power OutageR15ES028000 · NIEHS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI LIN, SHAO · 2018 to 2018
$444k
Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of PregnanR21ES021359 · NIEHS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI LIN, SHAO · 2012 to 2013
$321k
A Data Science Approach to Air Toxics and Children's Environmental HealthK99ES027022 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STINGONE, JEANETTE A · 2017 to 2018
$195k
ACL HHS U01DD001231EPA EP-D-18-001HSRD VA CDP 13-003NCBDD CDC HHS U01 DD001223NCBDD CDC HHS U01 DD001226NCBDD CDC HHS U01 DD001227NCBDD CDC HHS U01 DD001231NIA NIH HHS R01 AG070949NIEHS NIH HHS K99 ES027022NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P30 ES009089NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES027022NIEHS NIH HHS R15 ES028000NIEHS NIH HHS R21 ES021359
6 · The paper itself

Abstract

BACKGROUND/

objectiveResearch suggests gestational exposure to particulate matter ≤2.5 μm (PM

methodsWe identified CHD case children (n = 2824) and non-malformed live-birth control children (n = 4033) from pregnancies ending between 1999 and 2007 in the National Birth Defects Prevention Study, a U.S. population-based multicenter case-control study. We assigned mothers 6-week averages of PM

resultsConditional on the highest observed EHD count (15) and at least one critical period day during spring/summer, each 5 μg/m

conclusionsResults provide limited evidence that duration of extreme heat exposure modifies the PM

Indexed as

Air PollutantsExtreme HeatHeart Defects, CongenitalCase-Control StudiesChildFemaleHumansMaternal ExposureParticulate MatterPregnancyAir PollutantsParticulate MatterBirth outcomesCongenital heart defectsParticulate matterTemperature extremes

Identifiers

PMID34864029
PMCPMC8758551

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.