Evidence map›Paper›PMID 34863928›Full record

ArticleThe journal of allergy and clinical immunology. In practice2022

The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children.

Jonathan M Gaffin, Mario Castro, Leonard B Bacharier, Anne L Fuhlbrigge

Open access · greenAbstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Review
  5. Risk factors for asthma exacerbations.The journal of allergy and clinical immunology. Global · 2025
    Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Association of Obesity and Severe Asthma in Adults.Journal of clinical medicine · 2024
    Review
  14. Pediatric asthma comorbidities: Global impact and unmet needs.The World Allergy Organization journal · 2024
    Review
  15. Article
  16. Article
  17. Review
  18. Viral Infection and Airway Epithelial Immunity in Asthma.International journal of molecular sciences · 2022
    Review
  19. Economic burden of severe asthma treatment: A real-life study.The World Allergy Organization journal · 2022
    Article
  20. An Overview of the Obese-Asthma Phenotype in Children.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Jonathan M GaffinDivision of Pulmonary Medicine, Boston Children's Hospital, Boston, Mass. Electronic address: jonathan.gaffin@childrens.harvard.edu.
Mario CastroDivision of Pulmonary, Critical Care Medicine, University of Kansas School of Medicine, Kansas City, Kan.
Leonard B BacharierDivision of Pediatric Allergy, Immunology and Pulmonary Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tenn.
Anne L FuhlbriggePulmonary Sciences and Critical Care, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colo.
Boston Children's Hospital · USMonroe Carell Jr. Children's Hospital · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Kansas · US

Funding

Indoor Air Quality and Respiratory Morbidity in School-Aged Children with Bronchopulmonary DysplasiaR01ES030100 · NIEHS · BOSTON CHILDREN'S HOSPITAL · PI GAFFIN, JONATHAN MARK · 2019 to 2023
$3.7M
NIEHS NIH HHS R01 ES030100
6 · The paper itself

Abstract

Assessment of asthma comorbidities, conditions that adversely affect the pathobiology of asthma or impair its response to therapies, is a fundamental step in the evaluation and management of patients with difficult-to-treat asthma. Identifying and effectively treating asthma comorbidities, such as obesity, obstructive sleep apnea, and chronic sinusitis with nasal polyps, may improve asthma control and reduce exacerbations. In addition, identifying comorbid T2 inflammatory conditions may help guide optimal selection of biologic therapies. Here, we describe common comorbid conditions found in adult and pediatric difficult-to-control asthma, discuss evidence for the association with asthma morbidity and treatment benefit, and provide information on how and when to assess comorbidities.

Indexed as

AsthmaNasal PolypsSinusitisSleep Apnea, ObstructiveAdultChildComorbidityHumansAdultsChildrenComorbiditiesDifficult-to-control asthma

Identifiers

PMID34863928
PMCPMC8837696
OpenAlexW3217663533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.