Evidence map›Paper›PMID 34863883›Full record

ReviewResearch in microbiology

Fungal infections diagnosis - Past, present and future.

Alexandre Mendonça, Helena Santos, Ricardo Franco-Duarte, Paula Sampaio

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Research in microbiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. [Diagnostic Value of Serological Markers and Quantitative Real-Time PCR in Patients With Invasive Candidiasis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  13. Review
  14. First Case of Cutaneous Coinfection withDiagnostics (Basel, Switzerland) · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alexandre MendonçaCBMA (Centre of Molecular and Environmental Biology), Department of Biology, University of Minho, Braga, Portugal. Electronic address: alexandremendonca.1997@gmail.com.
Helena SantosCBMA (Centre of Molecular and Environmental Biology), Department of Biology, University of Minho, Braga, Portugal. Electronic address: helenaipsantos@hotmail.com.
Ricardo Franco-DuarteCBMA (Centre of Molecular and Environmental Biology), Department of Biology, University of Minho, Braga, Portugal. Electronic address: ricardofilipeduarte@bio.uminho.pt.
Paula SampaioCBMA (Centre of Molecular and Environmental Biology), Department of Biology, University of Minho, Braga, Portugal. Electronic address: psampaio@bio.uminho.pt.
University of Minho · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the scientific advances observed in the recent decades and the emergence of new methodologies, the diagnosis of systemic fungal infections persists as a problematic issue. Fungal cultivation, the standard method that allows a proven diagnosis, has numerous disadvantages, as low sensitivity (only 50% of the patients present positive fungal cultures), and long growth time. These are factors that delay the patient's treatment and, consequently, lead to higher hospital costs. To improve the accuracy and quickness of fungal infections diagnosis, several new methodologies attempt to be implemented in clinical microbiology laboratories. Most of these innovative methods are independent of pathogen isolation, which means that the diagnosis goes from being considered proven to probable. In spite of the advantage of being culture-independent, the majority of the methods lack standardization. PCR-based methods are becoming more and more commonly used, which has earned them an important place in hospital laboratories. This can be perceived now, as PCR-based methodologies have proved to be an essential tool fighting against the COVID-19 pandemic. This review aims to go through the main steps of the diagnosis for systemic fungal infection, from diagnostic classifications, through methodologies considered as "gold standard", to the molecular methods currently used, and finally mentioning some of the more futuristic approaches.

Indexed as

COVID-19MycosesHumansPandemicsPolymerase Chain ReactionFungal infections diagnosisGold standard methodologiesPCR-based methodologiesProbable diagnosisProven diagnosis

Identifiers

PMID34863883
PMCPMC8634697
OpenAlexW3214880083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.