Evidence map›Paper›PMID 34863818›Full record

ArticleJournal of immunological methods2022

Multiparameter immunohistochemistry analysis of HIV DNA, RNA and immune checkpoints in lymph node tissue.

Zuwena A Richardson, Claire Deleage, Candani S A Tutuka, Marzena Walkiewicz, Perla M Del Río-Estrada, Rachel D Pascoe, Vanessa A Evans, Gustavo Reyesteran, Michael Gonzales, Samuel Roberts-Thomson and 5 more

Open access · greenAbstract read
In one paragraph

Article in Journal of immunological methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Zuwena A RichardsonThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.
Claire DeleageFrederick National Laboratories for Cancer Research, MD, Frederick, United States of America.
Candani S A TutukaOlivia Newton John Cancer Centre Research Institute, Austin Hospital, Heidelberg, Australia; La Trobe School of Cancer Medicine, La Trobe University, Melbourne, Australia.
Marzena WalkiewiczOlivia Newton John Cancer Centre Research Institute, Austin Hospital, Heidelberg, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
Perla M Del Río-EstradaCentro de Investigación en Enfermdades Infecciosas, Instituto Nacional de Enfermedades Respiratoriras, Mexico City, Mexico.
Rachel D PascoeThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.
Vanessa A EvansThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.
Gustavo ReyesteranCentro de Investigación en Enfermdades Infecciosas, Instituto Nacional de Enfermedades Respiratoriras, Mexico City, Mexico.
Michael GonzalesPathology Department, The Royal Melbourne Hospital, Melbourne, Australia.
Samuel Roberts-ThomsonPathology Department, The Royal Melbourne Hospital, Melbourne, Australia.
Mauricio González-NavarroCentro de Investigación en Enfermdades Infecciosas, Instituto Nacional de Enfermedades Respiratoriras, Mexico City, Mexico.
Fernanda Torres-RuizCentro de Investigación en Enfermdades Infecciosas, Instituto Nacional de Enfermedades Respiratoriras, Mexico City, Mexico.
Jacob D EstesVaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health Science University, Portland, Oregon, USA.
Sharon R LewinThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia; Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Australia.
Paul U CameronThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia; La Trobe School of Cancer Medicine, La Trobe University, Melbourne, Australia; Launceston General Hospital, Tasmania, Launceston, Australia. Electronic address: paul.cameron@unimelb.edu.au.
The Royal Melbourne Hospital · AUInstituto Nacional de Enfermedades Respiratorias · MXFrederick National Laboratory for Cancer Research · USLa Trobe University · AUMonash University · AUOlivia Newton-John Cancer Wellness & Research Centre · AUOregon National Primate Research Center · USPeter Doherty Institute · AU

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9M
Attenuating Inflammation to Restore GI Tract Integrity and Reduce Viral Reservoirs During cARTR01DK119945 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI ESTES, JACOB D · 2018 to 2022
$3.8M
Novel ISH Approaches to Quantify Replication Competent ReservoirsR01AI143411 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI ESTES, JACOB D · 2019 to 2023
$3.6M
NCI NIH HHS 75N91019D00024NIAID NIH HHS R01 AI143411NIAID NIH HHS UM1 AI126611NIDDK NIH HHS R01 DK119945
6 · The paper itself

Abstract

The main barrier to a cure for HIV is the persistence of long-lived and proliferating latently infected CD4

Indexed as

ImmunohistochemistryIn Situ HybridizationDNA, ViralHIVHIV InfectionsHumansImmune Checkpoint InhibitorsJurkat CellsLatent InfectionLymph NodesPredictive Value of TestsRNA, ViralT-Lymphocytes, RegulatoryDNA, ViralImmune Checkpoint InhibitorsRNA, ViralHIV latencyImmune checkpointsImmunohistochemistryIn situ hybridizationLymph nodesMicroscopyRNAscope

Identifiers

PMID34863818
PMCPMC9036546
OpenAlexW3217175872

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.