Evidence map›Paper›PMID 34863581›Full record

ReviewTrends in ecology & evolution2022

Denisovans and Homo sapiens on the Tibetan Plateau: dispersals and adaptations.

Peiqi Zhang, Xinjun Zhang, Xiaoling Zhang, Xing Gao, Emilia Huerta-Sanchez, Nicolas Zwyns

Abstract readReview
In one paragraph

Review in Trends in ecology & evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peiqi ZhangDepartment of Anthropology, University of California, Davis, CA 95616, USA. Electronic address: zpeiqi@ucdavis.edu.
Xinjun ZhangDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA.
Xiaoling ZhangKey Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China; CAS Center for Excellence in Life and Paleoenvironment, Beijing 10044, China.
Xing GaoKey Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China; CAS Center for Excellence in Life and Paleoenvironment, Beijing 10044, China.
Emilia Huerta-SanchezDepartment of Ecology and Evolutionary Biology and Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA.
Nicolas ZwynsDepartment of Anthropology, University of California, Davis, CA 95616, USA; Department of Human Evolution, Max Planck Insititute for Evolutionary Anthropology, Leipzig 04103, Germany.

Funding

Population genomics of the selective effects of new mutationsR35GM119856 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LOHMUELLER, KIRK · 2016 to 2025
$3.4M
Characterizing modes of natural selection via diverse ancient and modern samplesR35GM128946 · NIGMS · BROWN UNIVERSITY · PI Emilia Huerta-Sanchez · 2018 to 2026
$3.1M
Dominance on the human genome and non-additive polygenic models for predicting complex traitsK99GM143466 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, XINJUN · 2021 to 2022
$125k
NIGMS NIH HHS K99 GM143466NIGMS NIH HHS R35 GM119856NIGMS NIH HHS R35 GM128946
6 · The paper itself

Abstract

Recent archaeological discoveries suggest that both archaic Denisovans and Homo sapiens occupied the Tibetan Plateau earlier than expected. Genetic studies show that a pulse of Denisovan introgression was involved in the adaptation of Tibetan populations to high-altitude hypoxia. These findings challenge the traditional view that the plateau was one of the last places on earth colonized by H. sapiens and warrant a reappraisal of the population history of this highland. Here, we integrate archaeological and genomic evidence relevant to human dispersal, settlement, and adaptation in the region. We propose two testable models to address the peopling of the plateau in the broader context of H. sapiens dispersal and their encounters with Denisovans in Asia.

Indexed as

Adaptation, PhysiologicalAltitudeAcclimatizationArchaeologyHumansTibetarchaeologyDenisovansgeneticshigh-altitude adaptationHomo sapienshuman population history

Identifiers

PMID34863581
PMCPMC9140327

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.