Evidence map›Paper›PMID 34863336›Full record

ArticleThe Lancet. Infectious diseases2022

Effect of preventive chemotherapy with praziquantel on schistosomiasis among school-aged children in sub-Saharan Africa: a spatiotemporal modelling study.

Christos Kokaliaris, Amadou Garba, Martin Matuska, Rachel N Bronzan, Daniel G Colley, Ameyo M Dorkenoo, Uwem F Ekpo, Fiona M Fleming, Michael D French, Achille Kabore and 14 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 142 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 4 pooled it
25.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 4 syntheses or guidelines pooled it, 208 citations in OpenAlex.

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  17. Plant-Derived Terpenes as Emerging Therapeutics Against Schistosomiasis.International journal of molecular sciences · 2026
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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 16 institutions in 10 countries.

Christos KokaliarisDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Amadou GarbaDepartment of Control of Neglected Tropical Diseases, WHO, Geneva, Switzerland.
Martin MatuskaDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Rachel N BronzanHealth & Development International, Newburyport, MA, USA.
Daniel G ColleySchistosomiasis Consortium for Operational Research and Evaluation, Center for Tropical and Emerging Global Diseases, and Department of Microbiology, University of Georgia, Athens, GA, USA.
Ameyo M DorkenooDepartment of Parasitology and Mycology, University of Lomé, Lomé, Togo.
Uwem F EkpoDepartment of Pure and Applied Zoology, Federal University of Agriculture, Abeokuta, Nigeria.
Fiona M FlemingSCI Foundation, London, UK.
Michael D FrenchRTI International, Washington DC, USA.
Achille KaboreFHI360, Washington DC, USA.
Jean B MbonigabaMalaria and Other Parasitic Disease Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Nicholas MidziDepartment of Medical Microbiology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Pauline N M MwinziCenter for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; Expanded Special Project for Elimination of Neglected Tropical Diseases, WHO, Regional Office for Africa, Brazzaville, Congo.
Eliézer K N'GoranUnité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire; Centre Suisse de Recherches Scientifiques en Côte d'Ivoire, Abidjan, Côte d'Ivoire.
Maria Rebollo PoloExpanded Special Project for Elimination of Neglected Tropical Diseases, WHO, Regional Office for Africa, Brazzaville, Congo.
Moussa SackoDepartment of Diagnostic and Biomedical Research, Institut National de Recherche en Santé Publique, Bamako, Mali.
Louis-Albert Tchuem TchuentéLaboratory of Parasitology and Ecology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon; Centre for Schistosomiasis and Parasitology, Yaoundé, Cameroon.
Edridah M TukahebwaVector Control Division, Ministry of Health, Kampala, Uganda.
Pitchouna A UvonNeglected Tropical Diseases Unit, Ministère de la Santé Publique, Kinshasa, Democratic Republic of the Congo.
Guojing YangDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Lisa WiesnerDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Yaobi ZhangRegional Office for Africa, Helen Keller International, Dakar, Senegal.
Jürg UtzingerDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Penelope VounatsouDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address: penelope.vounatsou@swisstph.ch.
University of Basel · CHSwiss Tropical and Public Health Institute · CHDrugs for Neglected Diseases Initiative · CHFamily Health International 360 · USFederal University of Agriculture · NGHealth & Development International · USHelen Keller International · USInstitut National de Recherche en Santé Publique · MLMinistry of Health · UGMinistry of Public Health · CDRTI International · USRwanda Biomedical Center · RWUniversity of Georgia · USUniversity of Lomé · TGUniversity of Zimbabwe · ZWWorld Health Organization Regional Office for Africa · CG

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundOver the past 20 years, schistosomiasis control has been scaled up. Preventive chemotherapy with praziquantel is the main intervention. We aimed to assess the effect of preventive chemotherapy on schistosomiasis prevalence in sub-Saharan Africa, comparing 2000-10 with 2011-14 and 2015-19.

methodsIn this spatiotemporal modelling study, we analysed survey data from school-aged children (aged 5-14 years) in 44 countries across sub-Saharan Africa. The data were extracted from the Global Neglected Tropical Diseases database and augmented by 2018 and 2019 survey data obtained from disease control programmes. Bayesian geostatistical models were fitted to Schistosoma haematobium and Schistosoma mansoni survey data. The models included data on climatic predictors obtained from satellites and other open-source environmental databases and socioeconomic predictors obtained from various household surveys. Temporal changes in Schistosoma species prevalence were estimated by a categorical variable with values corresponding to the three time periods (2000-10, 2011-14, and 2015-19) during which preventive chemotherapy interventions were scaled up.

findingsWe identified 781 references with relevant geolocated schistosomiasis survey data for 2000-19. There were 19 166 unique survey locations for S haematobium and 23 861 for S mansoni, of which 77% (14 757 locations for S haematobium and 18 372 locations for S mansoni) corresponded to 2011-19. Schistosomiasis prevalence among school-aged children in sub-Saharan Africa decreased from 23·0% (95% Bayesian credible interval 22·1-24·1) in 2000-10 to 9·6% (9·1-10·2) in 2015-19, an overall reduction of 58·3%. The reduction of S haematobium was 67·9% (64·6-71·1) and that of S mansoni 53·6% (45·2-58·3) when comparing 2000-10 with 2015-19.

interpretationOur model-based estimates suggest that schistosomiasis prevalence in sub-Saharan Africa has decreased considerably, most likely explained by the scale-up of preventive chemotherapy. There is a need to consolidate gains in the control of schistosomiasis by means of preventive chemotherapy, coupled with other interventions to interrupt disease transmission.

fundingEuropean Research Council and WHO.

Indexed as

Spatio-Temporal AnalysisAdolescentAfrica South of the SaharaAnimalsAnthelminticsChemopreventionChildChild, PreschoolCross-Sectional StudiesDatabases, FactualHumansPraziquantelPrevalenceSchistosoma haematobiumSchistosoma mansoniSchistosomiasisAnthelminticsPraziquantel

Identifiers

PMID34863336
PMCPMC8695385
OpenAlexW3216351002

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.