ArticleParasites & vectors2021
Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses.
Article in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited.International journal for parasitology. Drugs and drug resistance · 2023Pooled it
- Characterizing mixed strongyle infections in foals and broodmares using cytochrome c oxidase subunit I deep amplicon sequencing.Parasites & vectors · 2026Article
- Independent Development of Resistance to Main Classes of Anthelmintics by Gastrointestinal Nematodes of Ruminants and Horses.Pathogens (Basel, Switzerland) · 2025Article
- A pilot study on the potency of injectable vs. oral moxidectin formulation to suppress strongyle egg excretion in horses at twice lower dose.Helminthologia · 2025Article
- Australian guidelines for equine internal parasite management.Australian veterinary journal · 2025Review
- Unravelling the Effectiveness of Anthelmintic Treatments on Equine Strongyles on Irish Farms.Animals : an open access journal from MDPI · 2024Article
- The Use of Innovative Diagnostics to Inform Sustainable Control of Equine Helminth Infections.Pathogens (Basel, Switzerland) · 2023Review
- Horse and donkey parasitology: differences and analogies for a correct diagnostic and management of major helminth infections.Parasitology · 2023Review
- Epidemiological study on factors influencing the occurrence of helminth eggs in horses in Germany based on sent-in diagnostic samples.Parasitology research · 2023Article
- Assessment of worm control practices recommended by equine veterinarians in Australia.Frontiers in veterinary science · 2023Article
- Anthelmintic resistance in equine nematodes: Current status and emerging trends.International journal for parasitology. Drugs and drug resistance · 2022Review
- Equine strongylids: Ivermectin efficacy and fecal egg shedding patterns.Parasitology research · 2022Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCyathostomins are the most important and common parasitic nematodes of horses, with > 50 species known to occur worldwide. The frequent and indiscriminate use of anthelmintics has resulted in the development of anthelmintic resistance (AR) in horse nematodes. In this study we assessed the efficacy of commonly used anthelmintics against cyathostomins in Australian thoroughbred horses.
methodsTwo drug efficacy trials per farm were conducted on two thoroughbred horse farms in the state of Victoria, Australia. In the first trial, the horses on Farm A were treated with single and combinations of anthelmintics, including oxfendazole (OFZ), abamectin (ABM), abamectin and morantel (ABM + MOR), moxidectin (MOX) and oxfendazole and pyrantel (OFZ + PYR), at the recommended doses, whereas the horses on Farm B only received MOX, at the recommended dose. The faecal egg count reduction test (FECRT) was used to determine the efficacy and egg reappearance period (ERP) of anthelmintics. Based on the results of the first trial, the efficacies of MOX and a combination of ABM + MOR were reassessed to confirm their activities against cyathostomins.
resultsOf the five anthelmintic products tested on Farm A, resistance against OFZ, ABM and OFZ + PYR was found, with efficacies of - 41% (- 195% lower confidence limit [LCL]), 73% (60% LCL) and 82% (66% LCL) at 2 weeks post-treatment, respectively. The FECRT showed high efficacies of MOX and ABM + MOR (100%) at 2 week post-treatment and shortened ERPs for these anthelmintics (ABM + MOR: 4 weeks; MOX: 5 weeks). Resistance to MOX was found on Farm B, with a reduced efficacy of 90% (70% LCL) and 89% (82% LCL) at 2 weeks post-treatment in trials one and two, respectively.
conclusionsThis study provides the first evidence of MOX- and multidrug-resistant (ABM and combinations of anthelmintics) cyathostomins in Australia and indicates the need for continuous surveillance of the efficacy of currently effective anthelmintics and large-scale investigations to assess the ERP for various anthelmintics.
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