ArticleCritical care (London, England)2021
Novel protocol combining physical and nutrition therapies, Intensive Goal-directed REhabilitation with Electrical muscle stimulation and Nutrition (IGREEN) care bundle.
Article in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Comparative effectiveness of non-pharmacological interventions on health-related quality of life in ICU patients: a network meta-analysis.Frontiers in medicine · 2026Pooled it
- Resistance training and β-hydroxy-β-methylbutyrate for functional recovery in critical illness: a multicenter 2 × 2 factorial randomized trial.Critical care (London, England) · 2025Trial
- Effects of a multilevel intervention of resistance training with or without beta-hydroxy-beta-methylbutyrate in medical ICU patients during entire hospitalisation: a four-arm multicentre randomised controlled trial.Critical care (London, England) · 2023Trial
- Review
- Article
- J-shaped association between serum bicarbonate and 28-day ICU mortality in adult patients with sepsis: A multicenter cohort analysis.Medicine · 2026Article
- Dynamic changes in quadriceps and diaphragm thickness for early diagnosis of ICU-acquired weakness in elderly ICU patients: a prospective bedside ultrasound study.Frontiers in medicine · 2026Article
- Towards optimised nutrition therapy after critical illness: a position statement and research framework by the global research initiative on post-intensive care nutrition (GRIP) consortium.Critical care (London, England) · 2025Review
- Novel Strategies to Promote Intensive Care Unit Recovery via Personalized Exercise, Nutrition, and Anabolic Interventions.Critical care clinics · 2025Review
- Early Rehabilitation Interventions by Physical Therapists for Severe COVID-19 Patients Were Associated With Decreased Incidence of Post-ICU Physical Impairment.Annals of rehabilitation medicine · 2025Article
- Pre-Admission Predictors of Walking Independence in Critically Ill Patients.Respiratory care · 2024Article
- Nutritional therapy for the prevention of post-intensive care syndrome.Journal of intensive care · 2024Review
- Acute muscle loss assessed using panoramic ultrasound in critically ill adults: a prospective observational study.Journal of medical ultrasonics (2001) · 2024Observational
- A Predictive Nomogram for Intensive Care-Acquired Weakness after Cardiopulmonary Bypass.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2024Article
- Post-intensive care syndrome follow-up system after hospital discharge: a narrative review.Journal of intensive care · 2024Review
- Article
- Relationship between critical care nutrition and post-intensive care syndrome in surviving ventilated patients with COVID-19: a multicenter prospective observational study.Journal of clinical biochemistry and nutrition · 2024Article
- Risk Factors for Spinal Cord Injury during Endovascular Repair of Thoracoabdominal Aneurysm: Review of the Literature and Proposal of a Prognostic Score.Journal of clinical medicine · 2023Review
- The nitrogen load is affected by high protein provision according to kidney function in critically ill patients.Journal of clinical biochemistry and nutrition · 2023Article
- Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the combination of rehabilitation and nutrition may be important for the prevention of intensive care unit (ICU)-acquired weakness, a protocolized intervention of this combination has not yet been reported. We herein developed an original combined protocol and evaluated its efficacy.
methodsIn this single-center historical control study, we enrolled adult patients admitted to the ICU. Patients in the control group received standard care, while those in the intervention group received the protocol-based intervention. The ICU mobility scale was used to set goals for early mobilization and a neuromuscular electrical stimulation was employed when patients were unable to stand. The nutritional status was assessed for nutritional therapy, and target calorie delivery was set at 20 or 30 kcal/kg/day and target protein delivery at 1.8 g/kg/day in the intervention group. The primary endpoint was a decrease in femoral muscle volume in 10 days assessed by computed tomography.
resultsForty-five patients in the control group and 56 in the intervention group were included in the analysis. Femoral muscle volume loss was significantly lower in the intervention group (11.6 vs 14.5%, p = 0.03). The absolute risk difference was 2.9% (95% CI 0.1-5.6%). Early mobilization to a sitting position by day 10 was achieved earlier (p = 0.03), and mean calorie delivery (20.1 vs. 16.8 kcal/kg/day, p = 0.01) and mean protein delivery (1.4 vs. 0.8 g/kg/day, p < 0.01) were higher in the intervention group.
conclusionThe protocolized intervention, combining early mobilization and high-protein nutrition, contributed to the achievement of treatment goals and prevention of femoral muscle volume loss. TRIAL REGISTRATION NUMBER: The present study is registered at the University Hospital Medical Information Network-clinical trials registry (UMIN000040290, Registration date: May 7, 2020).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.