Evidence map›Paper›PMID 34863225›Full record

ArticleJournal of orthopaedic surgery and research2021

Rhizoma drynariae total flavonoids combined with calcium carbonate ameliorates bone loss in experimentally induced Osteoporosis in rats via the regulation of Wnt3a/β-catenin pathway.

Yimei Hu, Panyun Mu, Xu Ma, Jingru Shi, Zhendong Zhong, Lingyuan Huang

Open access · goldAbstract read
In one paragraph

Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Proteomic Analysis Based on TMT Regarding the Therapeutic Action ofCombinatorial chemistry & high throughput screening · 2024
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  9. Review
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  11. Effect ofFrontiers in endocrinology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yimei HuAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China. huyimei@cdutcm.edu.cn.ORCID http://orcid.org/0000-0001-9264-4740
Panyun MuAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
Xu MaAffiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
Jingru ShiChengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan, China.
Zhendong ZhongInstitute for Laboratory Animal Research, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Lingyuan HuangChengdu Lilai Biotechnology Co., LTD, Chengdu, China.
Chengdu University of Traditional Chinese Medicine · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRhizoma drynariae, a traditional Chinese herb, is commonly used in treatment of bone healing in osteoporotic fractures. However, whether the Rhizoma drynariae total flavonoids (RDTF) can promote the absorption of calcium and enhance the bone formation is unclear. The aim of the present study was to investigate the preventive effects of RDTF combined with calcium carbonate (CaCO

methodsThree-month-old Sprague-Dawley rats were ovariectomized (OVX) and then treated with CaCO

conclusionsRDTF combined with CaCO

Indexed as

OsteoporosisPolypodiaceaeAnimalsbeta CateninBone DensityCalcium CarbonateEstrogensFemaleFlavonoidsOvariectomyRANK LigandRatsRats, Sprague-DawleyWnt3A Proteinbeta CateninCalcium CarbonateEstrogensFlavonoidsRANK LigandWnt3A ProteinCalcium carbonateOsteoporosisRhizoma drynariae total flavonoidsWnt3a/β-catenin

Identifiers

PMID34863225
PMCPMC8642843
OpenAlexW4200168965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.