ArticleMicrobial cell factories2021
Evaluation of the anticarcinogenic potential of the endophyte, Streptomyces sp. LRE541 isolated from Lilium davidii var. unicolor (Hoog) Cotton.
Article in Microbial cell factories, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 15 citations in OpenAlex.
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- A Comprehensive Review of Kombucha Fermentation and Probiotic Functional Mechanisms: Microbial Dynamics, Bioactive Compounds and Health Effects.Probiotics and antimicrobial proteins · 2026Review
- A novel Umezawaea tangerina endophyte reveals anti-colorectal cancer activity and a rich biosynthetic landscape.Scientific reports · 2026Article
- Cost-Effective rhamnolipids production from corn Bran and their application in essential oil extraction.World journal of microbiology & biotechnology · 2026Article
- Characterization and Bioactive Metabolite Profiling ofMicroorganisms · 2024Article
- Chemical Constituents and Bioactivities of the Plant-Derived FungusMolecules (Basel, Switzerland) · 2024Article
- Description ofFrontiers in microbiology · 2024Article
- 4-Deoxy-Drug design, development and therapy · 2024Article
- Draft genome sequence ofMicrobiology resource announcements · 2023Article
- Isolation, Characterization of Pyraclostrobin Derived from Soil ActinomyceteAntibiotics (Basel, Switzerland) · 2023Article
- A swamp forest Streptomyces sp. strain KF15 with broad spectrum antifungal activity against chilli pathogens exhibits anticancer activity on HeLa cells.Archives of microbiology · 2022Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEndophytic actinomycetes, as emerging sources of bioactive metabolites, have been paid great attention over the years. Recent reports demonstrated that endophytic streptomycetes could yield compounds with potent anticancer properties that may be developed as chemotherapeutic drugs.
resultsHere, a total of 15 actinomycete-like isolates were obtained from the root tissues of Lilium davidii var. unicolor (Hoog) Cotton based on their morphological appearance, mycelia coloration and diffusible pigments. The preliminary screening of antagonistic capabilities of the 15 isolates showed that isolate LRE541 displayed antimicrobial activities against all of the seven tested pathogenic microorganisms. Further in vitro cytotoxicity test of the LRE541 extract revealed that this isolate possesses potent anticancer activities with IC
conclusionOur work evaluated the anticarcinogenic potential of the endophyte, Streptomyces sp. LRE541 and obtained one prenylated indole diketopiperazine alkaloid and two anthraquinones. Neoechinulin A, as a known antitumor agent, was identified for the first time in Streptomyces. Though previously found in Streptomyces, epsilon-pyrromycinone and 4-deoxy-ε-pyrromycinone were firstly shown to possess anticancer activities.
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