Evidence map›Paper›PMID 34862952›Full record

ReviewAdvances in therapy2022

The Role of Cetirizine in the Changing Landscape of IV Antihistamines: A Narrative Review.

Michael S Blaiss, Jonathan A Bernstein, Adam Kessler, Jesse M Pines, Carlos A Camargo, Paula Fulgham, Ryan Haumschild, Kristin Rupp, Timothy Tyler, Joseph Moellman

Open access · hybridAbstract readReview
In one paragraph

Review in Advances in therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Histamine in Diabetic Cardiovascular Complications.Reviews in cardiovascular medicine · 2026
    Review
  5. Article
  6. Diphenhydramine: A Review of Its Clinical Applications and Potential Adverse Effect Profile.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025
    Article
  7. Review
  8. Reversing Morphine Induced Tolerance: Insights Into Cetirizine and Green Tea Extract Efficacy.Current therapeutic research, clinical and experimental · 2025
    Article
  9. Intravenous Cetirizine Premedication to Mitigate Infusion-Related Reactions.Journal of the advanced practitioner in oncology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Michael S BlaissDepartment of Pediatrics, Medical College of Georgia at Augusta University, Augusta, Georgia. michael.blaiss@gmail.com.
Jonathan A BernsteinDepartment of Medicine, University of Cincinnati College of Medicine and Bernstein Allergy Group, Cincinnati, OH, USA.
Adam KesslerDepartment of Emergency Medicine, University of Alabama, Birmingham, AL, USA.
Jesse M PinesUS Acute Care Solutions, Canton, OH, USA.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Paula FulghamCancer Center of Kansas, Wichita, KS, USA.
Ryan HaumschildDepartment of Pharmaceutical Services, Emory University Hospital Midtown, and Winship Cancer Institute, Atlanta, GA, USA.
Kristin RuppComprehensive Cancer Center, Desert Regional Medical Center, Palm Springs, CA, USA.
Timothy TylerComprehensive Cancer Center, Desert Regional Medical Center, Palm Springs, CA, USA.
Joseph MoellmanDepartment of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Desert Regional Medical Center · USAugusta University · USBernstein Clinical Research Center · USCancer Center of Kansas · USEmory University Hospital Midtown · USMassachusetts General Hospital · USUniversity of Alabama at Birmingham · USUniversity of Cincinnati Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since 1955, the only available H

Indexed as

CetirizineUrticariaAdministration, IntravenousAdultDiphenhydramineHistamine H1 AntagonistsHumansCetirizineDiphenhydramineHistamine H1 AntagonistsAllergyAnaphylaxisAngioedemaAntihistamineCetirizineChemotherapyDiphenhydramineInfusionIntravenousUrticaria

Identifiers

PMID34862952
PMCPMC8643118
OpenAlexW3216010713

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.