Evidence map›Paper›PMID 34862821›Full record

ArticleAmerican journal of human biology : the official journal of the Human Biology Council2022

Associations between early marriage and preterm delivery: Evidence from lowland Nepal.

Faith A Miller, Akanksha A Marphatia, Jonathan C Wells, Mario Cortina-Borja, Dharma S Manandhar, Naomi M Saville

Open access · hybridAbstract read
In one paragraph

Article in American journal of human biology : the official journal of the Human Biology Council, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Early Marriage, Preterm Birth, and School Dropout: An Intergenerational Cycle of Risk?American journal of human biology : the official journal of the Human Biology Council · 2025
    Pooled it
  2. Article
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  4. The Maternal Capital Hypothesis: Giving Mothers Central Place in Evolutionary Perspectives on Developmental Plasticity and Health.American journal of human biology : the official journal of the Human Biology Council · 2025
    Review
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  11. Associations between early marriage and preterm delivery: Evidence from lowland Nepal.American journal of human biology : the official journal of the Human Biology Council · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Faith A MillerInstitute for Global Health (IGH), University College London (UCL), London, UK.ORCID 0000-0002-0766-7727
Akanksha A MarphatiaDepartment of Geography, University of Cambridge, Cambridge, UK.
Jonathan C WellsPopulation, Policy and Practice Research and Teaching Department, Great Ormond Street Institute of Child Health (ICH), University College London (UCL), London, UK.ORCID 0000-0003-0411-8025
Mario Cortina-BorjaPopulation, Policy and Practice Research and Teaching Department, Great Ormond Street Institute of Child Health (ICH), University College London (UCL), London, UK.
Dharma S ManandharMother and Infant Research Activities (MIRA), Kathmandu, Nepal.
Naomi M SavilleInstitute for Global Health (IGH), University College London (UCL), London, UK.ORCID 0000-0002-1735-3684
Great Ormond Street Hospital · GBThe George Institute for Global Health · GBMother and Infant Research Activities · NPUniversity of Cambridge · GB

Funding

Department of HealthMedical Research Council MR/N013867/1
6 · The paper itself

Abstract

objectivesPreterm delivery (<37 weeks gestation) is the largest cause of child mortality worldwide. Marriage and pregnancy during adolescence have been associated with an increased risk of preterm delivery. We investigate independent associations of age at marriage and age at first pregnancy with preterm delivery in a cohort of women from rural lowland Nepal.

methodsWe analyzed data from 17 974 women in the Low Birth Weight South Asia Trial. Logistic regression models tested associations of age at marriage and age at first pregnancy with preterm delivery, for primigravida (n = 6 243) and multigravida (n = 11 731) women. Models were adjusted for maternal education, maternal caste, and household asset score.

resultsNinety percent of participants had married at <18 years and 58% had their first pregnancy at <18 years. 20% of participants delivered preterm. Primigravida participants married at ≤14 years had higher odds of preterm delivery than those married ≥18 years, when adjusting for study design (adjusted odds ratio (aOR) 1.45, 95% CI: 1.15-1.83), confounders (aOR 1.28: 1.01-1.62) and confounders + age at pregnancy (aOR 1.29: 1.00-1.68). Associations were insignificant for multigravida women. No significant associations were observed between age at first pregnancy and preterm delivery. DISCUSSION: In this population, early marriage, rather than pregnancy, is a risk factor for preterm delivery. We hypothesize that psychological stress, a driver of preterm delivery which is increased among those marrying young, rather than physiological immaturity, drives this association. Further research into the psychological consequences of child marriage in Nepal is needed.

Indexed as

MarriagePremature BirthAdolescentFamily CharacteristicsFemaleHumansInfant, Low Birth WeightInfant, NewbornNepalPregnancy

Identifiers

PMID34862821
PMCPMC11475576
OpenAlexW3216395571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.