Evidence map›Paper›PMID 34862809›Full record

ArticleThe International journal of eating disorders2022

A 1-year follow-up study of the longitudinal interplay between emotion dysregulation and childhood trauma in the treatment of anorexia nervosa.

Emanuele Cassioli, Eleonora Rossi, Giulio D'Anna, Michela Martelli, Vivienne M Hazzard, Ross D Crosby, Stephen A Wonderlich, Valdo Ricca, Giovanni Castellini

Open access · hybridAbstract read
In one paragraph

Article in The International journal of eating disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Eye movement desensitization and reprocessingResearch in psychotherapy (Milano) · 2026
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  12. Does Evidence Support an Emotion Regulation Model of Anorexia Nervosa? A Systematic Review of Over a Decade of Research.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Emanuele CassioliPsychiatry Unit, Department of Health Sciences, University of Florence, Florence.ORCID 0000-0003-3623-7096
Eleonora RossiPsychiatry Unit, Department of Health Sciences, University of Florence, Florence.ORCID 0000-0003-4755-3879
Giulio D'AnnaPsychiatry Unit, Department of Health Sciences, University of Florence, Florence.
Michela MartelliPsychiatry Unit, Department of Health Sciences, University of Florence, Florence.
Vivienne M HazzardSanford Center for Biobehavioral Research, Fargo, North Dakota, USA.ORCID 0000-0003-3933-1766
Ross D CrosbySanford Center for Biobehavioral Research, Fargo, North Dakota, USA.
Stephen A WonderlichSanford Center for Biobehavioral Research, Fargo, North Dakota, USA.ORCID 0000-0002-0659-153X
Valdo RiccaPsychiatry Unit, Department of Health Sciences, University of Florence, Florence.
Giovanni CastelliniPsychiatry Unit, Department of Health Sciences, University of Florence, Florence.ORCID 0000-0003-1265-491X
University of Florence · ITSanford Research · US

Funding

Regional Postdoctoral Training Grant in Eating Disorders ResearchT32MH082761 · NIMH · UNIVERSITY OF MINNESOTA · PI CAROL B. PETERSON · 2009 to 2026
$6.2M
NIMH NIH HHS T32 MH082761
6 · The paper itself

Abstract

objectiveThe study aimed to investigate the complex relationship between eating disorder (ED) specific psychopathology, emotion dysregulation, and their longitudinal variations in patients with anorexia nervosa (AN) treated with a multidisciplinary approach including enhanced cognitive-behavior therapy (CBT-E), and to provide an integrated model which includes childhood trauma as a predictor of worse treatment outcomes.

methodIn total, 120 female patients with AN were evaluated at admission (T0), and 105 were re-evaluated after 1 year (T1) of treatment. At T0, patients underwent a clinical assessment and filled the Symptom Checklist 90-Revised (SCL90-R), the Eating Disorders Examination Questionnaire (EDE-Q), the Difficulties in Emotion Regulation Scale (DERS), and the Childhood Trauma Questionnaire (CTQ). SCL-90-R, EDE-Q, and DERS were readministered at T1. Variations between T0 and T1 were evaluated, and the proposed model was investigated using bivariate latent change score analysis in a structural equation modeling (SEM) framework.

resultsAn overall significant clinical amelioration was observed after treatment. A unidirectional effect of DERS scores on EDE-Q variations was outlined by SEM: patients with higher baseline DERS scores achieved less EDE-Q improvements, and EDE-Q latent change score was significantly predicted by longitudinal variations of DERS-but not vice versa. Higher CTQ scores predicted reduced treatment efficacy for ED-specific psychopathology through the mediating effect of higher baseline DERS scores. DISCUSSION: The present study sheds light on the mechanism by which early trauma compromises treatment outcome in patients with AN, underlining the crucial role of emotional dysregulation.

Indexed as

Adverse Childhood ExperiencesAnorexia NervosaEmotionsFemaleFollow-Up StudiesHumansSurveys and Questionnairesanorexia nervosabivariate latent change scorechildhood traumacognitive-behavior therapyemotion dysregulationlongitudinal structural equation modelingtreatment outcome

Identifiers

PMID34862809
PMCPMC8787461
OpenAlexW3215956939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.