ArticleESC heart failure2022
Diabetes and treatment of chronic heart failure in a large real-world heart failure population.
Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Influence of diabetes on sacubitril/valsartan titration and clinical outcomes in patients hospitalized for heart failure.ESC heart failure · 2023Trial
- Diabetic Foot Ulcers Are Clinical Marker of Disease Burden in People With Diabetes and Heart Failure.Diabetes, obesity & metabolism · 2026Article
- Guideline implementation, drug sequencing, and quality of care in heart failure: design and rationale of TITRATE-HF.ESC heart failure · 2024Article
- Use of loop diuretics in patients with chronic heart failure: an observational overview.Open heart · 2023Observational
- Diabetes Mellitus and Heart Failure: Epidemiology, Pathophysiologic Mechanisms, and the Role of SGLT2 Inhibitors.Life (Basel, Switzerland) · 2023Review
- Phenotypic patient profiling for improved implementation of guideline-directed medical therapy: An exploratory analysis in a large real-world chronic heart failure cohort.Frontiers in pharmacology · 2023Article
- Diabetes and treatment of chronic heart failure in a large real-world heart failure population.ESC heart failure · 2022Article
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Authors and funding
11 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAlthough diabetes mellitus (DM) is a common co-morbidity in chronic heart failure (HF) patients, European data on concurrent HF and DM treatment are lacking. Therefore, we have studied the HF treatment of patients with and without DM. Additionally, with the recent breakthrough of sodium-glucose cotransporter 2 (SGLT2) inhibitors in the field of HF, we studied the potential impact of this new drug in a large cohort of HF patients. METHODS AND
resultsA total of 7488 patients with chronic HF with a left ventricular ejection fraction <50% from 34 Dutch outpatient HF clinics between 2013 and 2016 were analysed on diabetic status and background HF therapy. Average age of the total population was 72.8 years (±11.7 years), and 64% of the patients were male. Diabetes was present in 29% of the patients (N = 2174). Diabetics had a worse renal function (mean estimated glomerular filtration rate 56 vs. 61 mL/min/1.73 m
conclusionsIn this large real-world HF registry, a high prevalence of DM was observed and diabetics more often received guideline-recommended target doses. Based on current evidence, the majority of patients would fulfil the enrichment criteria of SGLT2 trials in HF and the impact of this new drug class will be large.
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