ArticleHuman brain mapping2022
The "vestibular neuromatrix": A proposed, expanded vestibular network from graph theory in post-concussive vestibular dysfunction.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Time-resolved directional organization of brain networks: distinct strength and temporal signatures from neurophysiology to disease.bioRxiv : the preprint server for biology · 2026Article
- Vestibular Rehabilitation for Post-Concussive Vestibular Dysfunction: Pathophysiology, Evidence-Based Practice, and Future Perspectives.Korean journal of neurotrauma · 2026Review
- Time-Varying Directed Interactions in Functional Brain Networks: Modeling and Validation.ArXiv · 2026Article
- Relationship between vestibular alterations and cognitive performance in adults and older adults.CoDAS · 2026Observational
- Evaluation of the "RehabXR" virtual reality system for vestibular rehabilitation: evidence of changes in functional brain connectivity in warfighters with chronic mild traumatic brain injury.Frontiers in human neuroscience · 2026Article
- Warfarin use and vestibular dysfunction insights from NHANES data, network pharmacology, Mendelian randomization, and molecular docking.Scientific reports · 2025Article
- A virtual reality system for delivery of military-specific vestibular rehabilitation after mild traumatic brain injury: the Praxis study protocol.Frontiers in neurology · 2025Article
- Vestibular dysfunction leads to cognitive impairments: State of knowledge in the field and clinical perspectives (Review).International journal of molecular medicine · 2024Review
- Vestibular dysfunction and its association with cognitive impairment and dementia.Frontiers in neuroscience · 2024Review
- Eagle-449: A volumetric, whole-brain compilation of brain atlases for vestibular functional MRI research.Scientific data · 2023Article
- Brain-wide connectome inferences using functional connectivity MultiVariate Pattern Analyses (fc-MVPA).PLoS computational biology · 2022Article
- The "vestibular neuromatrix": A proposed, expanded vestibular network from graph theory in post-concussive vestibular dysfunction.Human brain mapping · 2022Article
- Vestibular dysfunction is an important contributor to the aging of visuospatial ability in older adults-Data from a computerized test system.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Convergent clinical and neuroimaging evidence suggests that higher vestibular function is subserved by a distributed network including visuospatial, cognitive-affective, proprioceptive, and integrative brain regions. Clinical vestibular syndromes may perturb this network, resulting in deficits across a variety of functional domains. Here, we leverage structural and functional neuroimaging to characterize this extended network in healthy control participants and patients with post-concussive vestibular dysfunction (PCVD). Then, 27 healthy control subjects (15 females) and 18 patients with subacute PCVD (12 female) were selected for participation. Eighty-two regions of interest (network nodes) were identified based on previous publications, group-wise differences in BOLD signal amplitude and connectivity, and multivariate pattern analysis on affective tests. Group-specific "core" networks, as well as a "consensus" network comprised of connections common to all participants, were then generated based on probabilistic tractography and functional connectivity between the 82 nodes and subjected to analyses of node centrality and community structure. Whereas the consensus network was comprised of affective, integrative, and vestibular nodes, PCVD participants exhibited diminished integration and centrality among vestibular and affective nodes and increased centrality of visual, supplementary motor, and frontal and cingulate eye field nodes. Clinical outcomes, derived from dynamic posturography, were associated with approximately 62% of all connections but best predicted by amygdalar, prefrontal, and cingulate connectivity. No group-wise differences in diffusion metrics or tractography were noted. These findings indicate that cognitive, affective, and proprioceptive substrates contribute to vestibular processing and performance and highlight the need to consider these domains during clinical diagnosis and treatment planning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.