Evidence map›Paper›PMID 34862445›Full record

ArticleScientific reports2021

Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections.

Karina-Doris Vihta, Nicola Claire Gordon, Nicole Stoesser, T Phuong Quan, Carina S B Tyrrell, Manivanh Vongsouvath, Elizabeth A Ashley, Vilada Chansamouth, Paul Turner, Clare L Ling and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Karina-Doris VihtaNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK. karina-doris.vihta@eng.ox.ac.uk.
Nicola Claire GordonLondon School of Hygiene and Tropical Medicine, London, UK.
Nicole StoesserNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
T Phuong QuanNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Carina S B TyrrellUniversity of Cambridge, Cambridge, UK.
Manivanh VongsouvathLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos.
Elizabeth A AshleyLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos.
Vilada ChansamouthLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Laos.
Paul TurnerCentre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Clare L LingCentre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
David W EyreNational Institute for Health Research Health Protection Research Unit, Oxford, UK.
Nicholas J WhiteCentre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Derrick CrookNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Tim E A PetoNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Ann Sarah WalkerNuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
University of Oxford · GBOxford University Hospitals NHS Trust · GBLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit · LAAngkor Hospital for Children · KHLondon School of Hygiene & Tropical Medicine · GBShoklo Malaria Research Unit · THUniversity of Cambridge · GB

Funding

Medical Research Council MR/K023985/1
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) surveillance in bloodstream infections (BSIs) is challenging in low/middle-income countries (LMICs) given limited laboratory capacity. Other specimens are easier to collect and process and are more likely to be culture-positive. In 8102 E. coli BSIs, 322,087 E. coli urinary tract infections, 6952 S. aureus BSIs and 112,074 S. aureus non-sterile site cultures from Oxfordshire (1998-2018), and other (55,296 isolates) rarer commensal opportunistic pathogens, antibiotic resistance trends over time in blood were strongly associated with those in other specimens (maximum cross-correlation per drug 0.51-0.99). Resistance prevalence was congruent across drug-years for each species (276/312 (88%) species-drug-years with prevalence within ± 10% between blood/other isolates). Results were similar across multiple countries in high/middle/low income-settings in the independent ATLAS dataset (103,559 isolates, 2004-2017) and three further LMIC hospitals/programmes (6154 isolates, 2008-2019). AMR in commensal opportunistic pathogens cultured from BSIs is strongly associated with AMR in commensal opportunistic pathogens cultured from non-sterile sites over calendar time, suggesting the latter could be used as an effective proxy for AMR surveillance in BSIs.

Indexed as

Drug Resistance, BacterialAnti-Bacterial AgentsAntimicrobial StewardshipCross InfectionDeveloping CountriesEscherichia coliHumansMicrobial Sensitivity TestsMicrobial ViabilityPrevalenceSepsisStaphylococcus aureusSymbiosisUrinary Tract InfectionsAnti-Bacterial Agents

Identifiers

PMID34862445
PMCPMC8642463
OpenAlexW3215438879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.