ArticleMolecular psychiatry2022
Dopamine and fear memory formation in the human amygdala.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 68 citations in OpenAlex.
- Dopamine D2/3 receptors and functional connectivity during fear extinction: A PET-fMRI study.Neuroimage. Reports · 2026Article
- Continuous infusion [European journal of nuclear medicine and molecular imaging · 2026Article
- Aberrant Fear: Biological Underpinnings Relevant to Psychosis, Antipsychotic Drugs, and Psychotherapeutic Treatments, a Translational Approach.International journal of molecular sciences · 2026Review
- Characterizing functional connectivity gradients for the hippocampus-amygdala complex in healthy and psychiatric cohorts.Brain structure & function · 2026Article
- Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The effects of encoding levels on the item and source memory of fearful and disgusting stimuli.BMC psychology · 2025Article
- Structural brain differences in school-aged children who are HIV-exposed uninfected.BMC medicine · 2025Article
- Article
- Integrating mind-body processes and motivational interviewing in health coaching: enhancing support for health behavior change.Frontiers in psychology · 2025Article
- Fear extinction retention in children, adolescents, and adults.Developmental cognitive neuroscience · 2025Article
- Dopaminergic drugs modulate fear extinction-related processes in humans, but effects are mild.Brain communications · 2025Article
- No evidence that post-training dopamine D2 receptor agonism affects fear generalization in male rats.Journal of psychopharmacology (Oxford, England) · 2024Article
- Central stress pathways in the development of cardiovascular disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Dopaminergic mesolimbic structural reserve is positively linked to better outcome after severe stroke.Brain communications · 2024Article
- Liver kinase B-1 modulates the activity of dopamine neurons in the ventral tegmental area and regulates social memory formation.Frontiers in molecular neuroscience · 2024Article
- Identification of Specific Abnormal Brain Functional Activity and Connectivity in Cancer Pain Patients: A Preliminary Resting-State fMRI Study.Journal of pain research · 2024Article
- The Neurotransmission Basis of Post-Traumatic Stress Disorders by the Fear Conditioning Paradigm.International journal of molecular sciences · 2023Review
- Spurious Autobiographical Memory of Psychosis: A Mechanistic Hypothesis for the Resolution, Persistence, and Recurrence of Positive Symptoms in Psychotic Disorders.Brain sciences · 2023Article
- Striatal dopamine transporter and receptor availability correlate with relative cerebral blood flow measured with [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Automatic and controlled attentional orienting toward emotional faces in patients with Parkinson's disease.Cognitive, affective & behavioral neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Learning which environmental cues that predict danger is crucial for survival and accomplished through Pavlovian fear conditioning. In humans and rodents alike, fear conditioning is amygdala-dependent and rests on similar neurocircuitry. Rodent studies have implicated a causative role for dopamine in the amygdala during fear memory formation, but the role of dopamine in aversive learning in humans is unclear. Here, we show dopamine release in the amygdala and striatum during fear learning in humans. Using simultaneous positron emission tomography and functional magnetic resonance imaging, we demonstrate that the amount of dopamine release is linked to strength of conditioned fear responses and linearly coupled to learning-induced activity in the amygdala. Thus, like in rodents, formation of amygdala-dependent fear memories in humans seems to be facilitated by endogenous dopamine release, supporting an evolutionary conserved neurochemical mechanism for aversive memory formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.