ArticleThe Journal of experimental medicine1986
Murine eosinophil differentiation factor. An eosinophil-specific colony-stimulating factor with activity for human cells.
Article in The Journal of experimental medicine, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Anti-IL-5 therapies for asthma.The Cochrane database of systematic reviews · 2022Pooled it
- Anti-IL5 therapies for asthma.The Cochrane database of systematic reviews · 2017Pooled it
- The molecular mechanism of circRNA_0021727 in inflammation of eosinophilic chronic rhinosinusitis.Frontiers in immunology · 2026Article
- A term infant with severe hypereosinophilia secondary to CMV infection and the STAT1 gene mutation: a case report : List of authors.BMC pediatrics · 2024Article
- Eosinophils in obesity and obesity-associated disorders.Discovery immunology · 2023Review
- Development of Mast Cell and Eosinophil Hyperplasia and HLH/MAS-Like Disease in NSG-SGM3 Mice Receiving Human CD34+ Hematopoietic Stem Cells or Patient-Derived Leukemia Xenografts.Veterinary pathology · 2021Article
- Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19.Scientific reports · 2020Article
- Eosinophils in Autoimmune Diseases.Frontiers in immunology · 2017Review
- Myeloid Cells in Asthma.Microbiology spectrum · 2017Review
- Recent advances in understanding eosinophil biology.F1000Research · 2017Review
- Pathogenesis of eosinophilic chronic rhinosinusitis.Journal of inflammation (London, England) · 2016Review
- Curcumin protects against nicotine-induced stress during protein malnutrition in female rat through immunomodulation with cellular amelioration.Molecular biology reports · 2015Article
- Novel targeted therapies for eosinophil-associated diseases and allergy.Annual review of pharmacology and toxicology · 2015Review
- IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- A (selective) history of Australian involvement in cytokine biology.Cytokine & growth factor reviews · 2013Review
- Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses.Biochimica et biophysica acta · 2011Article
- The role of eosinophils in non-parasitic infections.Endocrine, metabolic & immune disorders drug targets · 2011Review
- Eosinophils in innate immunity: an evolving story.Cell and tissue research · 2011Review
- Eosinophil survival and apoptosis in health and disease.Allergy, asthma & immunology research · 2010Article
- The clinical significance of eosinophils in the amniotic fluid in preterm labor.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A purified murine lymphokine, eosinophil differentiation factor (EDF), was found to be a selective stimulus for the clonal proliferation and differentiation of murine eosinophil progenitor cells, establishing it as the murine eosinophil colony-stimulating factor (Eo-CSF). EDF was also active on human eosinophil progenitors and mature blood eosinophils, but had no effect on neutrophil or macrophage precursor cells, nor on blood neutrophils. In culture of human bone marrow cells, EDF stimulated equal numbers and equal sizes of eosinophil colonies to develop when compared with human placental conditioned medium, a source of human CSFs, suggesting that all responsive progenitor cells were stimulated. Clone transfer experiments and the linear relationship between number of bone marrow cells plated and colonies produced confirmed that the action of EDF was directly on eosinophil progenitor cells. EDF increased the capacity of human blood eosinophils, but not neutrophils, to kill antibody-coated tumor cells and to phagocytose serum-opsonized yeast cells. This functional activation was associated with the enhanced expression of functional antigens (GFA-1, GFA-2, and the receptor for C3bi) on eosinophils. The possession by EDF (Eo-CSF) of all the properties expected of a human eosinophil CSF raises the possibility that a human analog of this molecule exists, and is involved in the regulation of production and function of human eosinophils in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.