Evidence map›Paper›PMID 34862305›Full record

Observational studyJournal of psychiatry & neuroscience : JPN

A translational exploration of the effects of

Yi-Ling Chien, Yu-Chieh Chen, Yen-Nan Chiu, Wen-Che Tsai, Susan Shur-Fen Gau

2 registry-linked trialsOpen access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00494754 completednot on this map

Clinical and Genetic Study of Autism Spectrum Disorder

TypeobservationalSponsorNational Taiwan University HospitalRan2007 to 2011Enrolled300ConditionsAutism
NCT01582256 completednot on this map

Behavior, Neuropsychology, Neuroimage and Electrophysiology in Autistic Individuals With and Without Copy Number Variation and Their Unaffected Siblings

TypeobservationalSponsorNational Taiwan University HospitalRan2012 to 2015Enrolled132ConditionsAutism
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yi-Ling ChienFrom the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan (Chien, Chen, Chiu, Tsai, Gau); and the Graduate Institute of Clinical Medicine, and Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan (Chen, Gau).
Yu-Chieh ChenFrom the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan (Chien, Chen, Chiu, Tsai, Gau); and the Graduate Institute of Clinical Medicine, and Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan (Chen, Gau).
Yen-Nan ChiuFrom the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan (Chien, Chen, Chiu, Tsai, Gau); and the Graduate Institute of Clinical Medicine, and Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan (Chen, Gau).
Wen-Che TsaiFrom the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan (Chien, Chen, Chiu, Tsai, Gau); and the Graduate Institute of Clinical Medicine, and Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan (Chen, Gau).
Susan Shur-Fen GauFrom the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan (Chien, Chen, Chiu, Tsai, Gau); and the Graduate Institute of Clinical Medicine, and Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan (Chen, Gau) gaushufe@ntu.edu.tw.
National Taiwan University Hospital · TWNational Taiwan University · TWTaipei Institute of Pathology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence suggests that cortical anatomy may be aytpical in autism spectrum disorder. The wingless-type MMTV integration site family, member 2

methodsIn a sample of 118 people with autism spectrum disorder and 122 typically developing controls, we investigated cortical thickness using FreeSurfer software. We then examined the main effects of the

resultsCompared to neurotypical controls, people with autism spectrum disorder showed reduced mean cortical thickness in both hemispheres and 9 cortical regions after false discovery rate correction, including the right cingulate gyrus, the orbital gyrus, the insula, the inferior frontal gyrus (orbital part and triangular part), the lateral occipitotemporal gyrus, the posterior transverse collateral sulcus, the lateral sulcus and the superior temporal sulcus. In the full sample, 2 SNPs of LIMITATIONS: We examined the genetic effect for each hemisphere and the 9 regions that were altered in autism spectrum disorder. The age effect we found in this cross-sectional study needs to be examined in longitudinal studies.

conclusionBased on neuroimaging and genetic data, our findings suggest that

trial registrationClinicalTrials.gov no. NCT01582256. PROTOCOL REGISTRATION: National Institutes of Health no. NCT00494754.

Indexed as

Autism Spectrum DisorderCerebral CortexCross-Sectional StudiesHumansMagnetic Resonance ImagingPolymorphism, Single NucleotideTemporal LobeWnt2 ProteinWnt2 ProteinWNT2 protein, human

Identifiers

PMID34862305
PMCPMC8648347
OpenAlexW3217087131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.