Evidence map›Paper›PMID 34862278›Full record

ArticleBMJ open2021

Using nasal povidone-iodine to prevent bloodstream infections and transmission of

Ana-Monica Racila, Amy M J O'Shea, Rajeshwari Nair, Kimberly Dukes, Loreen A Herwaldt, Linda Boyken, Daniel Diekema, Melissa A Ward, Jason Cobb, Jesse Jacob and 10 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04210505 (Povidone-iodine to Stop Access-related Infections and Transmission of Staphylococcus Aureus), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04210505 phase4active not recruitingnot on this map

Povidone-iodine to Stop Access-related Infections and Transmission of Staphylococcus Aureus (PAINTS)

TypeinterventionalSponsorMarin L. Schweizer, PhDRan2020 to 2024Enrolled302ConditionsStaphylococcus Aureus InfectionArmsPovidone-Iodine Topical Ointment, Standard Care
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Ana-Monica RacilaInternal Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA ana-monica-racila@uiowa.edu.ORCID 0000-0002-5751-5422
Amy M J O'SheaInternal Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
Rajeshwari NairInternal Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
Kimberly DukesInternal Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
Loreen A HerwaldtInternal Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
Linda BoykenInternal Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
Daniel DiekemaInternal Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
Melissa A WardInternal Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
Jason CobbRenal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Jesse JacobEmory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA.
David PeguesDepartment of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Susan BleasdaleDivision of Infectious Diseases, University of Illinois College of Medicine, Chicago, Illinois, USA.
Anitha VijayanDivision of Nephrology, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA.
Anubha MutnejaDivision of Nephrology, Washington University School of Medicine in Saint Louis, St Louis, Missouri, USA.
Mony FraerInternal Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
Debra O'Connell-MooreClinical Research Unit, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Pam TolomeoBiostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Minerva MendezDivision of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.
Erin JaworskiDepartment of Medicine, University of Illinois College of Medicine, Chicago, Illinois, USA.
Marin L SchweizerInternal Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
University of Iowa · USEmory University · USIllinois College · USUniversity of Pennsylvania · USWashington University in St. Louis · USUniversity of Iowa Hospitals and Clinics · US

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
Povidone-iodine to Stop Access-related Infections and Transmission of Staphylococcus aureus (PAINTS)R01HS026724 · AHRQ · UNIVERSITY OF WISCONSIN-MADISON · PI SCHWEIZER, MARIN LEIGH · 2019 to 2023
$2.3M
AHRQ HHS R01 HS026724NCATS NIH HHS UL1 TR002537
6 · The paper itself

Abstract

introductionApproximately 38% of haemodialysis patients carry METHODS AND ANALYSIS: We will perform an open-label, stepped-wedge cluster randomised trial to assess the effectiveness of nasal PVI compared with standard care. Sixteen outpatient haemodialysis units will participate in the study. The 3-year trial period will be divided into a 4-month baseline period and eight additional 4-month time blocks. The primary outcome of the study will be ETHICS AND DISSEMINATION: This study has received IRB approval from all study sites. A Data Safety and Monitoring Board will monitor this multicentre clinical trial. We will present our results at international meetings. The study team will publish findings in peer-reviewed journals and make each accepted peer-reviewed manuscript publicly available. TRIAL REGISTRATION NUMBER: NCT04210505.

Indexed as

SepsisStaphylococcal InfectionsHumansMulticenter Studies as TopicPovidone-IodineRandomized Controlled Trials as TopicRenal DialysisStaphylococcus aureusPovidone-Iodinedialysisinfection controlnephrologyqualitative research

Identifiers

PMID34862278
PMCPMC8647395
OpenAlexW3215522963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.