Trial reportClinical medicine (London, England)2021
The unspoken benefit of participation in a clinical trial.
Trial report in Clinical medicine (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- The Future is Local: the Role of Decentralised Clinical Trials in Patients with Advanced Cancer Receiving Palliative Care.Current treatment options in oncology · 2026Review
- Using marketing strategies to improve recruitment and retention in clinical trials: a scoping review.Trials · 2026Article
- Using Multi-Site Research Results to Impact Local Pediatric Pain Evidence-Based Practice: Innovations and Outcomes.Worldviews on evidence-based nursing · 2025Article
- Perceptions and attitudes toward clinical trial participation: a study onFrontiers in pharmacology · 2025Article
- The Australian clinical trial landscape: Perceptions of rural, regional and remote health service capacity and capability.Health research policy and systems · 2024Article
- HPTN 083-02: factors influencing adherence to injectable PrEP and retention in an injectable PrEP study.Journal of the International AIDS Society · 2024Article
- Seeing what others see while thinking what others have not.Clinical medicine (London, England) · 2021Article
- Refining Our "CRAFT": The Community Research Academy to Foster RepresenTation (CRAFT) Program.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundPublicly funded trials do not usually offer financial incentives to volunteers. An intensive level of medical care could act as an additional motivator for participation. Our aim was to establish whether patients may draw any clinical benefit from volunteering in a clinical trial.
methodsWe analysed the recruitment process of a phase II randomised controlled trial, the Inorganic Nitrate in Angina Study.
resultsTwo-hundred and thirteen patients with a history of stable angina and who had been under at least annual primary care review were screened for participation by history taking, examination, 12-lead electrocardiography, treadmill test and echocardiography. Thirty-five (16.4%) patients were found to have significant unstable or new clinical pathology, requiring urgent clinical attention. We identified 17 (7.9%) patients with unstable angina. Furthermore, we found new undiagnosed pathologies: amyloidosis in two (0.9%), hypertrophic cardiomyopathy in two (0.9%), left ventricular systolic dysfunction (ejection fraction <45%) in three (1.4%), left ventricular thrombus in one (0.4%), significant valvular disease in five (2.4%) and arrhythmias in six (2.8%).
conclusionCompared with routine care, patients screened for a clinical trial may come under an increased level of scrutiny that may affect their clinical management. This may act as additional motivator to attract patients to future studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.